Synthesis of narrow-polydispersity degradable dendronized aliphatic polyesters

Cameron C. Lee, Scott M. Grayson, Jean M.J. Fréchet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


The divergent dendronization of an ε-caprolactone-based polymer has been performed to provide access to dendronized polymers with sufficient biocompatibility and degradability for use as drug-delivery scaffolds. The synthesis was performed through the tin(II) 2-ethylhexanoate-catalyzed polymerization of a γ-functionalized ε-caprolactone monomer, followed by the divergent growth of pendant polyester dendrons at each repeat unit. The resulting dendronized polymers were obtained up to the fourth generation with molecular weights as high as 80,000 Da and with polydispersities between 1.11 and 1.22. The fourth-generation hydroxyl-terminated dendronized polymer was degradable under a variety of aqueous conditions. A comparison of the dendronization approach with a procedure involving the ring-opening polymerization of a second-generation dendritic macromonomer reveals that the former procedure is best suited for the preparation of this family of dendronized polyesters because it requires shorter reaction times and affords materials with higher degrees of polymerization.

Original languageEnglish (US)
Pages (from-to)3563-3578
Number of pages16
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number14
StatePublished - Jul 15 2004
Externally publishedYes


  • Biodegradable
  • Dendrimers
  • Dendronized polymers
  • Drug delivery systems
  • Polyesters

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry


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