Synthesis of mono- and symmetrical di-N-hydroxy- and N-aminoguanidines

Alan R. Katritzky; Niveen M. Khashab; Sergey Bobrov; Megumi Yoshioka

doi:10.1021/jo060793t

Synthesis of mono- and symmetrical di-N-hydroxy- and N-aminoguanidines

Alan R. Katritzky^*, Niveen M. Khashab, Sergey Bobrov, Megumi Yoshioka

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Novel mono- and symmetrical di-N-hydroxy- and N-aminoguanidines were readily prepared from the reaction of diverse hydroxylamines or hydrazines with reagent classes di(benzotriazol-1-yl)methanimine 6, (bis-benzotriazol-1-yl- methylene)amines 8a,b, benzotriazole-1-carboxamidines 10a-i, benzotriazole-1-carboximidamides 11a,b, and N′-hydroxy-1H-1,2,3- benzotriazole-1-carboximidamide 18. The preparation is described for a variety of N-hydroxy- and N-aminoguanidines with different substitution patterns in good yields.

Original language	English (US)
Pages (from-to)	6753-6758
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	71
Issue number	18
DOIs	https://doi.org/10.1021/jo060793t
State	Published - Sep 1 2006
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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title = "Synthesis of mono- and symmetrical di-N-hydroxy- and N-aminoguanidines",

abstract = "Novel mono- and symmetrical di-N-hydroxy- and N-aminoguanidines were readily prepared from the reaction of diverse hydroxylamines or hydrazines with reagent classes di(benzotriazol-1-yl)methanimine 6, (bis-benzotriazol-1-yl- methylene)amines 8a,b, benzotriazole-1-carboxamidines 10a-i, benzotriazole-1-carboximidamides 11a,b, and N′-hydroxy-1H-1,2,3- benzotriazole-1-carboximidamide 18. The preparation is described for a variety of N-hydroxy- and N-aminoguanidines with different substitution patterns in good yields.",

author = "Katritzky, {Alan R.} and Khashab, {Niveen M.} and Sergey Bobrov and Megumi Yoshioka",

year = "2006",

month = sep,

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doi = "10.1021/jo060793t",

language = "English (US)",

volume = "71",

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journal = "Journal of Organic Chemistry",

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T1 - Synthesis of mono- and symmetrical di-N-hydroxy- and N-aminoguanidines

AU - Katritzky, Alan R.

AU - Khashab, Niveen M.

AU - Bobrov, Sergey

AU - Yoshioka, Megumi

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Novel mono- and symmetrical di-N-hydroxy- and N-aminoguanidines were readily prepared from the reaction of diverse hydroxylamines or hydrazines with reagent classes di(benzotriazol-1-yl)methanimine 6, (bis-benzotriazol-1-yl- methylene)amines 8a,b, benzotriazole-1-carboxamidines 10a-i, benzotriazole-1-carboximidamides 11a,b, and N′-hydroxy-1H-1,2,3- benzotriazole-1-carboximidamide 18. The preparation is described for a variety of N-hydroxy- and N-aminoguanidines with different substitution patterns in good yields.

AB - Novel mono- and symmetrical di-N-hydroxy- and N-aminoguanidines were readily prepared from the reaction of diverse hydroxylamines or hydrazines with reagent classes di(benzotriazol-1-yl)methanimine 6, (bis-benzotriazol-1-yl- methylene)amines 8a,b, benzotriazole-1-carboxamidines 10a-i, benzotriazole-1-carboximidamides 11a,b, and N′-hydroxy-1H-1,2,3- benzotriazole-1-carboximidamide 18. The preparation is described for a variety of N-hydroxy- and N-aminoguanidines with different substitution patterns in good yields.

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U2 - 10.1021/jo060793t

DO - 10.1021/jo060793t

M3 - Article

C2 - 16930024

AN - SCOPUS:33750452291

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VL - 71

SP - 6753

EP - 6758

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 18

ER -

Synthesis of mono- and symmetrical di-N-hydroxy- and N-aminoguanidines

Abstract

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