TY - JOUR
T1 - Synthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C–H Borylation
AU - Batool, Farhat
AU - Parveen, Shehla
AU - Emwas, Abdul-Hamid M.
AU - Sioud, Salim
AU - Gao, Xin
AU - Munawar, Munawar A.
AU - Chotana, Ghayoor A.
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2015/8/17
Y1 - 2015/8/17
N2 - The preparation of fluoroalkoxy arylboronic esters by iridium-catalyzed aromatic C–H borylation is described. The fluoroalkoxy groups employed include trifluoromethoxy, difluoromethoxy, 1,1,2,2-tetrafluoroethoxy, and 2,2-difluoro-1,3-benzodioxole. The borylation reactions were carried out neat without the use of a glovebox or Schlenk line. The regioselectivities available through the iridium-catalyzed C–H borylation are complementary to those obtained by the electrophilic aromatic substitution reactions of fluoroalkoxy arenes. Fluoroalkoxy arylboronic esters can serve as versatile building blocks.
AB - The preparation of fluoroalkoxy arylboronic esters by iridium-catalyzed aromatic C–H borylation is described. The fluoroalkoxy groups employed include trifluoromethoxy, difluoromethoxy, 1,1,2,2-tetrafluoroethoxy, and 2,2-difluoro-1,3-benzodioxole. The borylation reactions were carried out neat without the use of a glovebox or Schlenk line. The regioselectivities available through the iridium-catalyzed C–H borylation are complementary to those obtained by the electrophilic aromatic substitution reactions of fluoroalkoxy arenes. Fluoroalkoxy arylboronic esters can serve as versatile building blocks.
UR - http://hdl.handle.net/10754/575662
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.5b02050
UR - http://www.scopus.com/inward/record.url?scp=84940991166&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.5b02050
DO - 10.1021/acs.orglett.5b02050
M3 - Article
C2 - 26278016
SN - 1523-7060
VL - 17
SP - 4256
EP - 4259
JO - Organic Letters
JF - Organic Letters
IS - 17
ER -