Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery

Shuaipeng Wang; Xiaowan Song; Xiaoshuang Feng; Peng Chen; Jiasheng Qian; Ru Xia; Jibin Miao

doi:10.1063/1674-0068/27/05/587-592

Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery

Shuaipeng Wang, Xiaowan Song, Xiaoshuang Feng, Peng Chen, Jiasheng Qian, Ru Xia, Jibin Miao

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.

Original language	English (US)
Pages (from-to)	587-592
Number of pages	6
Journal	Chinese Journal of Chemical Physics
Volume	27
Issue number	5
DOIs	https://doi.org/10.1063/1674-0068/27/05/587-592
State	Published - Oct 27 2014

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the National Natural Science Foundation of China (No.20804001, No.20974001, No.21174001, and No.51273001), the 211 Project, and the Incubation Fund for Excellent Young Researcher of Anhui University.

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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10.1063/1674-0068/27/05/587-592

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title = "Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery",

abstract = "Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.",

author = "Shuaipeng Wang and Xiaowan Song and Xiaoshuang Feng and Peng Chen and Jiasheng Qian and Ru Xia and Jibin Miao",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the National Natural Science Foundation of China (No.20804001, No.20974001, No.21174001, and No.51273001), the 211 Project, and the Incubation Fund for Excellent Young Researcher of Anhui University.",

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AU - Song, Xiaowan

AU - Feng, Xiaoshuang

AU - Chen, Peng

AU - Qian, Jiasheng

AU - Xia, Ru

AU - Miao, Jibin

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the National Natural Science Foundation of China (No.20804001, No.20974001, No.21174001, and No.51273001), the 211 Project, and the Incubation Fund for Excellent Young Researcher of Anhui University.

PY - 2014/10/27

Y1 - 2014/10/27

N2 - Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.

AB - Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.

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Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery

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