Abstract
A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.
Original language | English (US) |
---|---|
Pages (from-to) | 11771-11775 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 23 |
Issue number | 49 |
DOIs | |
State | Published - Sep 4 2017 |
Bibliographical note
Publisher Copyright:© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
- C−N activation
- amide
- amine
- nickel catalysis
- synthetic methods
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Organic Chemistry