Synthesis, HSA-Binding and Anticancer Properties of [Cu2(μ -dppm)2(N^N)2]2+

Bandar A. Babgi, Najah A. Alzaidi, Jalal H. Alsayari, Abdul-Hamid M. Emwas, Mariusz Jaremko, Magda H. Abdellattif, Mutlaq Aljahdali, Mostafa A. Hussien

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1 Scopus citations


A set of dinuclear copper(I) complexes with the general formula [Cu2(μ-dppm)2(N^N)2]2+ were synthesized and characterized by 1HNMR, 31PNMR, and elemental analysis. The high-resolution mass spectra clearly illustrated isotopic pattern for the proposed dinuclear systems. The binding of the complexes toward human serum albumin (HSA) were evaluated, highlighting good binding affinities influenced by the nature of the substituted-diimine. The complexes induce changes in both the α-helix and the microenvironment structures of HSA. The HSA-bindings were modelled by molecular docking; [Cu2(μ-dppm)2(dppz)2][ClO4]2 (3) displays the highest binding score toward HSA due to the ability of dppz in establishing π-interactions. The anticancer properties of 1, 2 and 3 were screened against COLO 205, RCC-PR, HepGII and LLC-MK2 cell lines and the results were discussed. Complex 3 has better IC50 against all the cancer cell lines than that observed for cisplatin, but still lower than the cytotoxicity of Sunitinib. Moreover, complex 3 has higher selectivity towards cancer cells over normal cells when compared to cisplatin and sunitinib. Graphical Abstract: [Figure not available: see fulltext.].

Bibliographical note

KAUST Repository Item: Exported on 2022-07-04
Acknowledgements: This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia under grant no. (G-1436-130-43). The authors, therefore, acknowledge with thanks DSR technical and financial support.

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics


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