Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands

Muhammad Altaf; M. Monim-ul-Mehboob; Adam A.A. Seliman; Manzar Sohail; Mohammed I.M. Wazeer; Anvarhusein A. Isab; L. Li; V. Dhuna; G. Bhatia; K. Dhuna

doi:10.1016/j.ejmech.2015.03.019

Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands

Muhammad Altaf, M. Monim-ul-Mehboob, Adam A.A. Seliman, Manzar Sohail, Mohammed I.M. Wazeer, Anvarhusein A. Isab, L. Li, V. Dhuna, G. Bhatia, K. Dhuna

King Abdullah University of Science and Technology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.

Original language	English (US)
Pages (from-to)	464-472
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	95
DOIs	https://doi.org/10.1016/j.ejmech.2015.03.019
State	Published - Mar 10 2015

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01

ASJC Scopus subject areas

Organic Chemistry
Drug Discovery
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2015.03.019

https://repository.kaust.edu.sa/bitstream/10754/348543/1/1-s2.0-S0223523415001865-main.pdf

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Altaf, M., Monim-ul-Mehboob, M., Seliman, A. A. A., Sohail, M., Wazeer, M. I. M., Isab, A. A., Li, L., Dhuna, V., Bhatia, G., & Dhuna, K. (2015). Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands. European Journal of Medicinal Chemistry, 95, 464-472. https://doi.org/10.1016/j.ejmech.2015.03.019

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title = "Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands",

abstract = "Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.",

author = "Muhammad Altaf and M. Monim-ul-Mehboob and Seliman, {Adam A.A.} and Manzar Sohail and Wazeer, {Mohammed I.M.} and Isab, {Anvarhusein A.} and L. Li and V. Dhuna and G. Bhatia and K. Dhuna",

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doi = "10.1016/j.ejmech.2015.03.019",

language = "English (US)",

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Altaf, M, Monim-ul-Mehboob, M, Seliman, AAA, Sohail, M, Wazeer, MIM, Isab, AA, Li, L, Dhuna, V, Bhatia, G & Dhuna, K 2015, 'Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands', European Journal of Medicinal Chemistry, vol. 95, pp. 464-472. https://doi.org/10.1016/j.ejmech.2015.03.019

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T1 - Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands

AU - Altaf, Muhammad

AU - Monim-ul-Mehboob, M.

AU - Seliman, Adam A.A.

AU - Sohail, Manzar

AU - Wazeer, Mohammed I.M.

AU - Isab, Anvarhusein A.

AU - Li, L.

AU - Dhuna, V.

AU - Bhatia, G.

AU - Dhuna, K.

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2015/3/10

Y1 - 2015/3/10

N2 - Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.

AB - Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.

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SN - 0223-5234

VL - 95

SP - 464

EP - 472

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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Other files and links

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CCDC 946806: Experimental Crystal Structure Determination : (Dimethylcarbamodithioato)-(tri-t-butylphosphine)-gold(i)

CCDC 946805: Experimental Crystal Structure Determination : (Diethylcarbamodithioato)-(tri-t-butylphosphine)-gold(i)

Cite this

Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 946806: Experimental Crystal Structure Determination : (Dimethylcarbamodithioato)-(tri-t-butylphosphine)-gold(i)

CCDC 946805: Experimental Crystal Structure Determination : (Diethylcarbamodithioato)-(tri-t-butylphosphine)-gold(i)

Cite this