Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite

Sherif M.A.S. Keshk; Adel A. El-Zahhar; Qana A. Alsulami; Abdullah G. Al-Sehemi; Mariusz Jaremko; Samir Bondock; Thomas Heinze

doi:10.1007/s10570-019-02887-y

Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite

Sherif M.A.S. Keshk, Adel A. El-Zahhar, Qana A. Alsulami, Abdullah G. Al-Sehemi, Mariusz Jaremko, Samir Bondock, Thomas Heinze

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Abstract

In this study, a magnetically enhanced drug delivery composite was synthesized by co-precipitating magnetite nanoparticle (MNP) with 2,3-dialdehyde cellulose-6-phosphate (DACP) and investigated for ampyrone drug loading and controlled delivery. The magnetic core containing Fe3O4 was synthesized through the intramolecular Cannizzaro reaction during the in situ preparation of MNPs in the presence of sodium hydroxide solution, producing hydroxyl acid cellulose phosphate (HACP). The prepared magnetite nanocomposite MNP/HACP was characterized using FT-IR, SEM–EDX, XRD, TEM, VSM and TGA. The release profiles of ampyrone loaded on MNP/HACP showed a continuous release rate of more than 95% after 50 h, compared to the lower release rate of DACP, where only 60% of the loaded ampyrone was released after 50 h. These results show that MNP/HACP nanocomposites present an enhanced loading-release system with the potential to act as a magnetically enhanced drug delivery system.

Original language	English (US)
Pages (from-to)	1603-1618
Number of pages	16
Journal	Cellulose
Volume	27
Issue number	3
DOIs	https://doi.org/10.1007/s10570-019-02887-y https://doi.org/10.1007/s10570-019-02911-1
State	Published - Nov 27 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through research groups program under Grant Number R.G.P. 1/19/40. Thomas Heinze acknowledged financially supported by the DFG-funded Collaborative Research Centre PolyTarget (SFB 1278, Project A02).

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Keshk, S. M. A. S., El-Zahhar, A. A., Alsulami, Q. A., Al-Sehemi, A. G., Jaremko, M., Bondock, S., & Heinze, T. (2019). Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite. Cellulose, 27(3), 1603-1618. https://doi.org/10.1007/s10570-019-02887-y, https://doi.org/10.1007/s10570-019-02911-1

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title = "Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite",

abstract = "In this study, a magnetically enhanced drug delivery composite was synthesized by co-precipitating magnetite nanoparticle (MNP) with 2,3-dialdehyde cellulose-6-phosphate (DACP) and investigated for ampyrone drug loading and controlled delivery. The magnetic core containing Fe3O4 was synthesized through the intramolecular Cannizzaro reaction during the in situ preparation of MNPs in the presence of sodium hydroxide solution, producing hydroxyl acid cellulose phosphate (HACP). The prepared magnetite nanocomposite MNP/HACP was characterized using FT-IR, SEM–EDX, XRD, TEM, VSM and TGA. The release profiles of ampyrone loaded on MNP/HACP showed a continuous release rate of more than 95% after 50 h, compared to the lower release rate of DACP, where only 60% of the loaded ampyrone was released after 50 h. These results show that MNP/HACP nanocomposites present an enhanced loading-release system with the potential to act as a magnetically enhanced drug delivery system.",

author = "Keshk, {Sherif M.A.S.} and El-Zahhar, {Adel A.} and Alsulami, {Qana A.} and Al-Sehemi, {Abdullah G.} and Mariusz Jaremko and Samir Bondock and Thomas Heinze",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through research groups program under Grant Number R.G.P. 1/19/40. Thomas Heinze acknowledged financially supported by the DFG-funded Collaborative Research Centre PolyTarget (SFB 1278, Project A02).",

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doi = "10.1007/s10570-019-02887-y",

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T1 - Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite

AU - Keshk, Sherif M.A.S.

AU - El-Zahhar, Adel A.

AU - Alsulami, Qana A.

AU - Al-Sehemi, Abdullah G.

AU - Jaremko, Mariusz

AU - Bondock, Samir

AU - Heinze, Thomas

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through research groups program under Grant Number R.G.P. 1/19/40. Thomas Heinze acknowledged financially supported by the DFG-funded Collaborative Research Centre PolyTarget (SFB 1278, Project A02).

PY - 2019/11/27

Y1 - 2019/11/27

N2 - In this study, a magnetically enhanced drug delivery composite was synthesized by co-precipitating magnetite nanoparticle (MNP) with 2,3-dialdehyde cellulose-6-phosphate (DACP) and investigated for ampyrone drug loading and controlled delivery. The magnetic core containing Fe3O4 was synthesized through the intramolecular Cannizzaro reaction during the in situ preparation of MNPs in the presence of sodium hydroxide solution, producing hydroxyl acid cellulose phosphate (HACP). The prepared magnetite nanocomposite MNP/HACP was characterized using FT-IR, SEM–EDX, XRD, TEM, VSM and TGA. The release profiles of ampyrone loaded on MNP/HACP showed a continuous release rate of more than 95% after 50 h, compared to the lower release rate of DACP, where only 60% of the loaded ampyrone was released after 50 h. These results show that MNP/HACP nanocomposites present an enhanced loading-release system with the potential to act as a magnetically enhanced drug delivery system.

AB - In this study, a magnetically enhanced drug delivery composite was synthesized by co-precipitating magnetite nanoparticle (MNP) with 2,3-dialdehyde cellulose-6-phosphate (DACP) and investigated for ampyrone drug loading and controlled delivery. The magnetic core containing Fe3O4 was synthesized through the intramolecular Cannizzaro reaction during the in situ preparation of MNPs in the presence of sodium hydroxide solution, producing hydroxyl acid cellulose phosphate (HACP). The prepared magnetite nanocomposite MNP/HACP was characterized using FT-IR, SEM–EDX, XRD, TEM, VSM and TGA. The release profiles of ampyrone loaded on MNP/HACP showed a continuous release rate of more than 95% after 50 h, compared to the lower release rate of DACP, where only 60% of the loaded ampyrone was released after 50 h. These results show that MNP/HACP nanocomposites present an enhanced loading-release system with the potential to act as a magnetically enhanced drug delivery system.

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DO - 10.1007/s10570-019-02887-y

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JO - Cellulose

JF - Cellulose

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ER -

Synthesis, characterization and ampyrone drug release behavior of magnetite nanoparticle/2,3-dialdehyde cellulose-6-phosphate composite

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