Synthesis and conformations of dendronized poly(L-lysine)

Cameron C. Lee; Jean M.J. Fréchet

doi:10.1021/ma052078b

Synthesis and conformations of dendronized poly(L-lysine)

Cameron C. Lee, Jean M.J. Fréchet

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Dendronized polymers based on a poly(L-lysine) backbone have been synthesized up to the fourth generation. The hydroxyl-terminated polymers are completely water-soluble, which makes them good candidates for drug delivery applications. The dendronized polypeptide backbones are helical at lower generations, but undergo a dramatic conformational change from α-helical to disordered upon increasing the dendron size to the third generation. This conformational change, attributed to steric repulsions between dendrons, is supported by spectroscopic measurements, while chain extension upon dendronization is confirmed by scanning force microscopy.

Original language	English (US)
Pages (from-to)	476-481
Number of pages	6
Journal	Macromolecules
Volume	39
Issue number	2
DOIs	https://doi.org/10.1021/ma052078b
State	Published - Jan 24 2006
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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AB - Dendronized polymers based on a poly(L-lysine) backbone have been synthesized up to the fourth generation. The hydroxyl-terminated polymers are completely water-soluble, which makes them good candidates for drug delivery applications. The dendronized polypeptide backbones are helical at lower generations, but undergo a dramatic conformational change from α-helical to disordered upon increasing the dendron size to the third generation. This conformational change, attributed to steric repulsions between dendrons, is supported by spectroscopic measurements, while chain extension upon dendronization is confirmed by scanning force microscopy.

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Synthesis and conformations of dendronized poly(L-lysine)

Abstract

ASJC Scopus subject areas

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