Synthesis and characterization of SiO2-CaO-P2O 5 hollow nanospheres for biomedical applications

G. S. Pappas, P. Bilalis, G. C. Kordas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A ternary system of SiO2-CaO-P2O5 hollow nanospheres has been successfully prepared by sol-gel method using polystyrene (PS) nanospheres as template. The inorganic shell was produced using tetraorthosilicate (TEOS) as the silica source and tri-calciumphospate as calcium and phosphorus sources, respectively. The positive surface charge of the template and the [template]/[TEOS] ratio were the key parameters for the creation of a stable primary inorganic network and the further growth of the shell. The removal of the polymeric core through a thermal treatment procedure created an inner void space with mean diameter 250 nm while the outer mean diameter was 330 nm.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalMaterials Letters
Issue number1
StatePublished - Jan 15 2012
Externally publishedYes

Bibliographical note

Funding Information:
This work was funded by the European Research Council (ERC) under the project “NANOTHERAPY” with reference number 232959.


  • Bioceramics
  • Biomaterials
  • Hollow nanospheres
  • Sol-gel preparation

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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