Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.

Daniela Laricchiuta, Juliette Gimenez, Giuseppe Sciamanna, Andrea Termine, Carlo Fabrizio, Francesco Della Valle, Silvia Caioli, Luana Saba, Marco De Bardi, Francesca Balsamo, Anna Panuccio, Noemi Passarello, Anna Mattioni, Elisa Bisicchia, Cristina Zona, Valerio Orlando, Laura Petrosini

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive fear extinction. We find that, already before fear conditioning, specific morphological, electrophysiological, and transcriptomic patterns of cortical and amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, we show the possibility to rescue inefficient fear extinction by activating infralimbic pyramidal neurons and to impair fear extinction by activating prelimbic pyramidal neurons.
Original languageEnglish (US)
Pages (from-to)113066
JournalCell reports
Issue number9
StatePublished - Aug 31 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-09-04
Acknowledged KAUST grant number(s): BAS 01/01
Acknowledgements: This work was partially supported by the Italian Ministry of Health (grant number GR-2018-12365733 to D.L. and G.S.) and Ricerca Corrente Fondazione Santa Lucia (to L.P.), and by KAUST BAS 01/01 (to V.O.). Parts of the graphical abstract were created using BioRender.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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