Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.

Daniela Laricchiuta; Juliette Gimenez; Giuseppe Sciamanna; Andrea Termine; Carlo Fabrizio; Francesco Della Valle; Silvia Caioli; Luana Saba; Marco De Bardi; Francesca Balsamo; Anna Panuccio; Noemi Passarello; Anna Mattioni; Elisa Bisicchia; Cristina Zona; Valerio Orlando; Laura Petrosini

doi:10.1016/j.celrep.2023.113066

Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.

Daniela Laricchiuta, Juliette Gimenez, Giuseppe Sciamanna, Andrea Termine, Carlo Fabrizio, Francesco Della Valle, Silvia Caioli, Luana Saba, Marco De Bardi, Francesca Balsamo, Anna Panuccio, Noemi Passarello, Anna Mattioni, Elisa Bisicchia, Cristina Zona, Valerio Orlando, Laura Petrosini

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive fear extinction. We find that, already before fear conditioning, specific morphological, electrophysiological, and transcriptomic patterns of cortical and amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, we show the possibility to rescue inefficient fear extinction by activating infralimbic pyramidal neurons and to impair fear extinction by activating prelimbic pyramidal neurons.

Original language	English (US)
Pages (from-to)	113066
Journal	Cell reports
Volume	42
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2023.113066
State	Published - Aug 31 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-09-04
Acknowledged KAUST grant number(s): BAS 01/01
Acknowledgements: This work was partially supported by the Italian Ministry of Health (grant number GR-2018-12365733 to D.L. and G.S.) and Ricerca Corrente Fondazione Santa Lucia (to L.P.), and by KAUST BAS 01/01 (to V.O.). Parts of the graphical abstract were created using BioRender.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2023.113066

https://repository.kaust.edu.sa/bitstream/10754/694035/1/1-s2.0-S221112472301077X-main.pdf

Cite this

Laricchiuta, D., Gimenez, J., Sciamanna, G., Termine, A., Fabrizio, C., Della Valle, F., Caioli, S., Saba, L., De Bardi, M., Balsamo, F., Panuccio, A., Passarello, N., Mattioni, A., Bisicchia, E., Zona, C., Orlando, V., & Petrosini, L. (2023). Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction. Cell reports, 42(9), 113066. https://doi.org/10.1016/j.celrep.2023.113066

@article{041633b86c7b4a7784ce13ddd0f1a49d,

title = "Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.",

abstract = "Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive fear extinction. We find that, already before fear conditioning, specific morphological, electrophysiological, and transcriptomic patterns of cortical and amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, we show the possibility to rescue inefficient fear extinction by activating infralimbic pyramidal neurons and to impair fear extinction by activating prelimbic pyramidal neurons.",

author = "Daniela Laricchiuta and Juliette Gimenez and Giuseppe Sciamanna and Andrea Termine and Carlo Fabrizio and {Della Valle}, Francesco and Silvia Caioli and Luana Saba and {De Bardi}, Marco and Francesca Balsamo and Anna Panuccio and Noemi Passarello and Anna Mattioni and Elisa Bisicchia and Cristina Zona and Valerio Orlando and Laura Petrosini",

note = "KAUST Repository Item: Exported on 2023-09-04 Acknowledged KAUST grant number(s): BAS 01/01 Acknowledgements: This work was partially supported by the Italian Ministry of Health (grant number GR-2018-12365733 to D.L. and G.S.) and Ricerca Corrente Fondazione Santa Lucia (to L.P.), and by KAUST BAS 01/01 (to V.O.). Parts of the graphical abstract were created using BioRender.",

year = "2023",

month = aug,

day = "31",

doi = "10.1016/j.celrep.2023.113066",

language = "English (US)",

volume = "42",

pages = "113066",

journal = "Cell reports",

issn = "2211-1247",

publisher = "Elsevier",

number = "9",

}

Laricchiuta, D, Gimenez, J, Sciamanna, G, Termine, A, Fabrizio, C, Della Valle, F, Caioli, S, Saba, L, De Bardi, M, Balsamo, F, Panuccio, A, Passarello, N, Mattioni, A, Bisicchia, E, Zona, C, Orlando, V & Petrosini, L 2023, 'Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.', Cell reports, vol. 42, no. 9, pp. 113066. https://doi.org/10.1016/j.celrep.2023.113066

TY - JOUR

T1 - Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.

AU - Laricchiuta, Daniela

AU - Gimenez, Juliette

AU - Sciamanna, Giuseppe

AU - Termine, Andrea

AU - Fabrizio, Carlo

AU - Della Valle, Francesco

AU - Caioli, Silvia

AU - Saba, Luana

AU - De Bardi, Marco

AU - Balsamo, Francesca

AU - Panuccio, Anna

AU - Passarello, Noemi

AU - Mattioni, Anna

AU - Bisicchia, Elisa

AU - Zona, Cristina

AU - Orlando, Valerio

AU - Petrosini, Laura

N1 - KAUST Repository Item: Exported on 2023-09-04 Acknowledged KAUST grant number(s): BAS 01/01 Acknowledgements: This work was partially supported by the Italian Ministry of Health (grant number GR-2018-12365733 to D.L. and G.S.) and Ricerca Corrente Fondazione Santa Lucia (to L.P.), and by KAUST BAS 01/01 (to V.O.). Parts of the graphical abstract were created using BioRender.

PY - 2023/8/31

Y1 - 2023/8/31

N2 - Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive fear extinction. We find that, already before fear conditioning, specific morphological, electrophysiological, and transcriptomic patterns of cortical and amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, we show the possibility to rescue inefficient fear extinction by activating infralimbic pyramidal neurons and to impair fear extinction by activating prelimbic pyramidal neurons.

AB - Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive fear extinction. We find that, already before fear conditioning, specific morphological, electrophysiological, and transcriptomic patterns of cortical and amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, we show the possibility to rescue inefficient fear extinction by activating infralimbic pyramidal neurons and to impair fear extinction by activating prelimbic pyramidal neurons.

UR - http://hdl.handle.net/10754/694035

UR - https://linkinghub.elsevier.com/retrieve/pii/S221112472301077X

U2 - 10.1016/j.celrep.2023.113066

DO - 10.1016/j.celrep.2023.113066

M3 - Article

C2 - 37656620

SN - 2211-1247

VL - 42

SP - 113066

JO - Cell reports

JF - Cell reports

IS - 9

ER -

Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction.

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this