TY - CHAP
T1 - Sustainable separations in pharmaceutical manufacturing
AU - Ignacz, Gergo
AU - Orkenyi, Robert
AU - Konczol, Arpad
AU - Szekely, Gyorgy
N1 - KAUST Repository Item: Exported on 2022-09-26
PY - 2022/9/2
Y1 - 2022/9/2
N2 - The pharmaceutical industry is gradually shifting toward a green and sustainable future. Separation technologies during downstream processing contribute greatly to the waste generation of pharmaceutical manufacturing that needs to be mitigated. This chapter focuses on the sustainability of liquid–liquid separation methodologies from chromatography through crystallization to membrane technologies. As the application of continuous technologies in the pharma sector continues to increase rapidly, the chapter highlights the sustainable aspects of continuous liquid chromatography, capillary electrophoresis, organic solvent nanofiltration and crystallization. The work presented here also summarizes the current trends in the field, discusses relevant case studies, and underlies the predicted future of separation processes for pharma products.
AB - The pharmaceutical industry is gradually shifting toward a green and sustainable future. Separation technologies during downstream processing contribute greatly to the waste generation of pharmaceutical manufacturing that needs to be mitigated. This chapter focuses on the sustainability of liquid–liquid separation methodologies from chromatography through crystallization to membrane technologies. As the application of continuous technologies in the pharma sector continues to increase rapidly, the chapter highlights the sustainable aspects of continuous liquid chromatography, capillary electrophoresis, organic solvent nanofiltration and crystallization. The work presented here also summarizes the current trends in the field, discusses relevant case studies, and underlies the predicted future of separation processes for pharma products.
UR - http://hdl.handle.net/10754/681642
UR - https://linkinghub.elsevier.com/retrieve/pii/B9780128222485000085
U2 - 10.1016/b978-0-12-822248-5.00008-5
DO - 10.1016/b978-0-12-822248-5.00008-5
M3 - Chapter
SP - 155
EP - 200
BT - Contemporary Chemical Approaches for Green and Sustainable Drugs
PB - Elsevier
ER -
