Sustainable separations in pharmaceutical manufacturing

Gergo Ignacz, Robert Orkenyi, Arpad Konczol, Gyorgy Szekely

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The pharmaceutical industry is gradually shifting toward a green and sustainable future. Separation technologies during downstream processing contribute greatly to the waste generation of pharmaceutical manufacturing that needs to be mitigated. This chapter focuses on the sustainability of liquid–liquid separation methodologies from chromatography through crystallization to membrane technologies. As the application of continuous technologies in the pharma sector continues to increase rapidly, the chapter highlights the sustainable aspects of continuous liquid chromatography, capillary electrophoresis, organic solvent nanofiltration and crystallization. The work presented here also summarizes the current trends in the field, discusses relevant case studies, and underlies the predicted future of separation processes for pharma products.
Original languageEnglish (US)
Title of host publicationContemporary Chemical Approaches for Green and Sustainable Drugs
PublisherElsevier
Pages155-200
Number of pages46
DOIs
StatePublished - Sep 2 2022

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