Sustainable Manganese-Catalyzed Solvent-Free Synthesis of Pyrroles from 1,4-Diols and Primary Amines

Jannik C. Borghs, Yury Lebedev, Magnus Rueping, Osama El-Sepelgy

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A general and selective metal-catalyzed conversion of biomass-derived primary diols and amines to the highly valuable 2,5-unsubstituted pyrroles has been developed. The reaction is catalyzed by a stable nonprecious manganese complex (1 mol %) in the absence of organic solvents whereby water and molecular hydrogen are the only side products. The manganese catalyst shows unprecedented selectivity, avoiding the formation of pyrrolidines, cyclic imides, and lactones.
Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalOrganic Letters
Issue number1
StatePublished - Dec 24 2018

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