Survey of the visual exploration and analysis of perfusion data

Bernhard Preim*, Steffen Oeltze, Matej Mlejnek, Eduard Gröller, Anja Hennemuth, Sarah Behrens

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Dynamic contrast-enhanced image data (perfusion data) are used to characterize regional tissue perfusion. Perfusion data consist of a sequence of images, acquired after a contrast agent bolus is applied. Perfusion data are used for diagnostic purposes in oncology, ischemic stroke assessment or myocardial ischemia. The diagnostic evaluation of perfusion data is challenging, since the data is complex and exhibits various artifacts, e.g., motion artifacts. We provide an overview on existing methods to analyze, and visualize CT and MR perfusion data. The integrated visualization of several 2D parameter maps, the 3D visualization of parameter volumes and exploration techniques are discussed. An essential aspect in the diagnosis of perfusion data is the correlation between perfusion data and derived time-intensity curves as well as with other image data, in particular with high resolution morphologic image data. We discuss visualization support with respect to the three major application areas: ischemic stroke diagnosis, breast tumor diagnosis and the diagnosis of coronary heart disease.

Original languageEnglish (US)
Article number4569838
Pages (from-to)205-220
Number of pages16
JournalIEEE Transactions on Visualization and Computer Graphics
Issue number2
StatePublished - Mar 2009
Externally publishedYes


  • Medical visualization
  • Multiparameter visualization
  • Perfusion data
  • Volume rendering

ASJC Scopus subject areas

  • Software
  • Signal Processing
  • Computer Vision and Pattern Recognition
  • Computer Graphics and Computer-Aided Design


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