Supported Lipid Bilayer Assembly on PEDOT:PSS Films and Transistors

Yi Zhang, Sahika Inal, Chih Yun Hsia, Magali Ferro, Marc Ferro, Susan Daniel*, Roisin M. Owens

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Lipid bilayers are widely employed as a model system to investigate interactions between cells and their environment. Supported lipid bilayers (SLB) with integrated transmembrane proteins are emerging as a preferred platform for sensing applications. Challenges lie in the generation of SLB on surfaces which allow transduction of signals for characterization of lipid bilayer and incorporated transmembrane proteins. For the first time, the formation of SLBs is shown on films of the conducting polymer, poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate) (PEDOT:PSS), using traditional methods for characterizing lipid bilayer quality and function (QCM-D, FRAP) combined with impedance spectroscopy. Further, partial formation of SLBs on PEDOT:PSS based organic electrochemical transistors (OECTs) is successfully demonstrated, as well as the ability to integrate and sense the ion pore α-hemolysin, confirming the sensitivity of the OECT as a transducer of biological membrane function. This work represents a highly promising first step toward the use of such OECTs for functional readout of transmembrane proteins in their native environment.

Original languageEnglish (US)
Pages (from-to)7304-7313
Number of pages10
JournalAdvanced Functional Materials
Issue number40
StatePublished - Oct 25 2016

Bibliographical note

Publisher Copyright:
© 2016 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • OECT
  • bioelectronics
  • supported lipid bilayers
  • vesicle fusion

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Condensed Matter Physics
  • General Materials Science
  • Electrochemistry
  • Biomaterials


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