Strategies for developing pH sensitive fluorescent probes

Mikhail Y. Berezin; Kevin Guo; Hyeran Lee; Walter Akers; Adah Almutairi; Jean M J Fréchet; Samuel Achilefu

doi:10.1117/12.849452

Strategies for developing pH sensitive fluorescent probes

Mikhail Y. Berezin, Kevin Guo, Hyeran Lee, Walter Akers, Adah Almutairi, Jean M J Fréchet, Samuel Achilefu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases associated with elevated acidity level. We present several strategies for the development of pH sensitive probes suitable for in vivo imaging. The strategies include incorporation of pH sensitive functionalities in known fluorophores, synthesis of novel pH sensitive skeletons, and design of pH sensitive nanoparticles using acid-degradable polymers.

Original language	English (US)
Title of host publication	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
Volume	7576
DOIs	https://doi.org/10.1117/12.849452
State	Published - 2010
Externally published	Yes
Event	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II - San Francisco, CA, United States Duration: Jan 25 2010 → Jan 27 2010

Other

Other	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
Country/Territory	United States
City	San Francisco, CA
Period	01/25/10 → 01/27/10

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.849452

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title = "Strategies for developing pH sensitive fluorescent probes",

abstract = "Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases associated with elevated acidity level. We present several strategies for the development of pH sensitive probes suitable for in vivo imaging. The strategies include incorporation of pH sensitive functionalities in known fluorophores, synthesis of novel pH sensitive skeletons, and design of pH sensitive nanoparticles using acid-degradable polymers.",

author = "Berezin, {Mikhail Y.} and Kevin Guo and Hyeran Lee and Walter Akers and Adah Almutairi and Fr{\'e}chet, {Jean M J} and Samuel Achilefu",

year = "2010",

doi = "10.1117/12.849452",

language = "English (US)",

isbn = "9780819479723",

volume = "7576",

booktitle = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II",

note = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II ; Conference date: 25-01-2010 Through 27-01-2010",

}

Berezin, MY, Guo, K, Lee, H, Akers, W, Almutairi, A, Fréchet, JMJ & Achilefu, S 2010, Strategies for developing pH sensitive fluorescent probes. in Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II. vol. 7576, 75760F, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, San Francisco, CA, United States, 01/25/10. https://doi.org/10.1117/12.849452

TY - GEN

T1 - Strategies for developing pH sensitive fluorescent probes

AU - Berezin, Mikhail Y.

AU - Guo, Kevin

AU - Lee, Hyeran

AU - Akers, Walter

AU - Almutairi, Adah

AU - Fréchet, Jean M J

AU - Achilefu, Samuel

PY - 2010

Y1 - 2010

N2 - Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases associated with elevated acidity level. We present several strategies for the development of pH sensitive probes suitable for in vivo imaging. The strategies include incorporation of pH sensitive functionalities in known fluorophores, synthesis of novel pH sensitive skeletons, and design of pH sensitive nanoparticles using acid-degradable polymers.

AB - Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases associated with elevated acidity level. We present several strategies for the development of pH sensitive probes suitable for in vivo imaging. The strategies include incorporation of pH sensitive functionalities in known fluorophores, synthesis of novel pH sensitive skeletons, and design of pH sensitive nanoparticles using acid-degradable polymers.

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U2 - 10.1117/12.849452

DO - 10.1117/12.849452

M3 - Conference contribution

AN - SCOPUS:77951824698

SN - 9780819479723

VL - 7576

BT - Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II

T2 - Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II

Y2 - 25 January 2010 through 27 January 2010

ER -

Strategies for developing pH sensitive fluorescent probes

Abstract

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