Statistical model for OCT image denoising

Muxingzi Li, Ramzi Idoughi, Biswarup Choudhury, Wolfgang Heidrich

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Optical coherence tomography (OCT) is a non-invasive technique with a large array of applications in clinical imaging and biological tissue visualization. However, the presence of speckle noise affects the analysis of OCT images and their diagnostic utility. In this article, we introduce a new OCT denoising algorithm. The proposed method is founded on a numerical optimization framework based on maximum-a-posteriori estimate of the noise-free OCT image. It combines a novel speckle noise model, derived from local statistics of empirical spectral domain OCT (SD-OCT) data, with a Huber variant of total variation regularization for edge preservation. The proposed approach exhibits satisfying results in terms of speckle noise reduction as well as edge preservation, at reduced computational cost.

Original languageEnglish (US)
Article number#297591
Pages (from-to)3903-3917
Number of pages15
JournalBiomedical Optics Express
Issue number9
StatePublished - Sep 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Optical Society of America.


  • Image enhancement
  • Noise in imaging systems
  • Optical coherence tomography
  • Speckle
  • Statistical optics

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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