Spys Make Asymmetric Chromatin

Molecular processes that occur on symmetric substrates can theoretically produce symmetric or asymmetric outcomes. When nonrandom but controlled and directed, symmetry vs asymmetry can establish complexity and signaling potential. Biological processes often take advantage of discriminating symmetry vs asymmetry, and studying such processes requires molecular and chemical methods that capture the complexity of the natural systems. In this issue of ACS Central Science, Muir and co-workers describe an advanced strategy for making asymmetric chromatin in the test tube.