Solubility of cannabinol in supercritical carbon dioxide

Helene Perrotin-Brunel*, Maaike J.E. Van Roosmalen, Maaike C. Kroon, Jaap Van Spronsen, Geert-Jan Witkamp, Cor J. Peters

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-Δ9-tetrahydrocannabinol (Δ9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to Δ9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).

Original languageEnglish (US)
Pages (from-to)3704-3707
Number of pages4
JournalJournal of Chemical and Engineering Data
Issue number9
StatePublished - Sep 9 2010

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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