Solubility of Δ9-tetrahydrocannabinol in supercritical carbon dioxide: Experiments and modeling

Helene Perrotin-Brunel; Pablo Cabeza Perez; Maaike J.E. van Roosmalen; Jaap van Spronsen; Geert Jan Witkamp; Cor J. Peters

doi:10.1016/j.supflu.2009.12.001

Solubility of Δ⁹-tetrahydrocannabinol in supercritical carbon dioxide: Experiments and modeling

Helene Perrotin-Brunel^*, Pablo Cabeza Perez, Maaike J.E. van Roosmalen, Jaap van Spronsen, Geert Jan Witkamp, Cor J. Peters

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The solubility of Δ⁹-tetrahydrocannabinol (Δ⁹-THC) in supercritical carbon dioxide has been determined at 315, 327, 334 and 345 K and in the pressure range from 13.2 to 25.1 MPa using an analytical method with a quasi-flow apparatus. Prior to performing these measurements, the method was validated by measuring anthracene solubilities and comparing these with literature values. The molar solubility for Δ⁹-THC ranged from 0.20 to 2.95 × 10^-4. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from 4.1 to 13.3% absolute average relative deviation (AARD).

Original language	English (US)
Pages (from-to)	6-10
Number of pages	5
Journal	Journal of Supercritical Fluids
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/j.supflu.2009.12.001
State	Published - Feb 2010
Externally published	Yes

Keywords

Anthracene
Peng-Robinson equation of state
Solubility
Supercritical carbon dioxide
Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

General Chemical Engineering
Condensed Matter Physics
Physical and Theoretical Chemistry

Access to Document

10.1016/j.supflu.2009.12.001

Cite this

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title = "Solubility of Δ9-tetrahydrocannabinol in supercritical carbon dioxide: Experiments and modeling",

abstract = "The solubility of Δ9-tetrahydrocannabinol (Δ9-THC) in supercritical carbon dioxide has been determined at 315, 327, 334 and 345 K and in the pressure range from 13.2 to 25.1 MPa using an analytical method with a quasi-flow apparatus. Prior to performing these measurements, the method was validated by measuring anthracene solubilities and comparing these with literature values. The molar solubility for Δ9-THC ranged from 0.20 to 2.95 × 10-4. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from 4.1 to 13.3% absolute average relative deviation (AARD).",

keywords = "Anthracene, Peng-Robinson equation of state, Solubility, Supercritical carbon dioxide, Δ-Tetrahydrocannabinol",

author = "Helene Perrotin-Brunel and Perez, {Pablo Cabeza} and {van Roosmalen}, {Maaike J.E.} and {van Spronsen}, Jaap and Witkamp, {Geert Jan} and Peters, {Cor J.}",

year = "2010",

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AU - Perrotin-Brunel, Helene

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AU - van Spronsen, Jaap

AU - Witkamp, Geert Jan

AU - Peters, Cor J.

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