Solid-Phase Synthesis of Oligosaccharides. I. Preparation of the Solid Support. Poly[p-(1-propen-3-ol-1-yl)styrene]

Solid-phase synthesis of oligosaccharides requires the use of a saccharide derivative with a reactive leaving group at C-1, one hydroxyl protected by a readily removable blocking group, the remaining hydroxyls protected by a stable blocking group, and a resin which can be separated from the formed oligosaccharide derivative without removing the alcoholic substituents. A polystyrene resin with allyl alcohol functional groups has been prepared and a procedure for the solid-phase synthesis of oligosaccharides has been tested with an appropriately substituted glycosyl halide.