Solid-Phase Synthesis of Oligosaccharides. I. Preparation of the Solid Support. Poly[p-(1-propen-3-ol-1-yl)styrene]

Jean M. Frechet, Conrad Schuerch

Research output: Contribution to journalArticlepeer-review

305 Scopus citations


Solid-phase synthesis of oligosaccharides requires the use of a saccharide derivative with a reactive leaving group at C-1, one hydroxyl protected by a readily removable blocking group, the remaining hydroxyls protected by a stable blocking group, and a resin which can be separated from the formed oligosaccharide derivative without removing the alcoholic substituents. A polystyrene resin with allyl alcohol functional groups has been prepared and a procedure for the solid-phase synthesis of oligosaccharides has been tested with an appropriately substituted glycosyl halide.

Original languageEnglish (US)
Pages (from-to)492-496
Number of pages5
JournalJournal of the American Chemical Society
Issue number2
StatePublished - Jan 1 1971
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


Dive into the research topics of 'Solid-Phase Synthesis of Oligosaccharides. I. Preparation of the Solid Support. Poly[p-(1-propen-3-ol-1-yl)styrene]'. Together they form a unique fingerprint.

Cite this