Solid lipid nanoparticles (SLNs) as a rising tool in drug delivery science: One step up in nanotechnology

Shivani Rai, Rishi Paliwal, Prem N. Gupta, Kapil Khatri, Amit K. Goyal, Bhuvaneshwar Vaidya, S. P. Vyas

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Colloid science has now been reframed in advance form as nanotechnology. Novel nanoparticulate carrier systems could make an important impact on clinical practice, not only in the field of targeted drug delivery but also for the delivery of diagnostic agents, gene therapy and vaccine delivery as well. Polymer based nanoparticles are full of numerous advantages in delivery science but at the same time they suffer from toxicity considerations and problems in industrial scale up of the formulations. Lipid based carrier systems i.e. emulsions, liposomes etc. have been tried to solve such problems related to the delivery technology. Currently lipid-based nanoparticles gained much interest as they combine both the technology of lipid sciences and nanosciences, and hence may be better alternative carriers. Many aspects related to the development of solid lipid nanoparticles (SLNs) like production technology, effect of process parameters, selection of ingredients and route of delivery are important for the industrial applications of nanoscience. In the present review a detail discussion of methods of production of solid lipid nanoparticles, influence of ingredients of composition on product quality, therapeutic moiety effect, characterization parameters and effects of sterilization have been focused. Role of solid lipid nanoparticles for controlled and targeted drug delivery, utility as a novel transfection agent and their potential as adjuvant for vaccine delivery are summed up in addition. Clinical therapeutics of SLNs in terms of advantages and limitations of various routes of delivery of SLNs has also been explored for the further advancement of practical applications of solid lipid nanoparticles. © 2008 Bentham Science Publishers Ltd.
Original languageEnglish (US)
Pages (from-to)30-44
Number of pages15
JournalCurrent Nanoscience
Issue number1
StatePublished - Feb 1 2008
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering
  • Pharmaceutical Science
  • Biotechnology
  • Medicine (miscellaneous)


Dive into the research topics of 'Solid lipid nanoparticles (SLNs) as a rising tool in drug delivery science: One step up in nanotechnology'. Together they form a unique fingerprint.

Cite this