Snap-top nanocarriers

Michael W. Ambrogio; Travis A. Pecorelli; Kaushik I. Patel; Niveen M. Khashab; Ali Trabolsi; Hussam A. Khatib; Youssry Y. Botros; Jeffrey I. Zink; Fraser Fraser Raser Stoddart

doi:10.1021/ol101286a

Snap-top nanocarriers

Michael W. Ambrogio, Travis A. Pecorelli, Kaushik I. Patel, Niveen M. Khashab, Ali Trabolsi, Hussam A. Khatib, Youssry Y. Botros, Jeffrey I. Zink, Fraser Fraser Raser Stoddart

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

(Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles. © 2010 American Chemical Society.

Original language	English (US)
Pages (from-to)	3304-3307
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	15
DOIs	https://doi.org/10.1021/ol101286a
State	Published - Aug 6 2010

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Physical and Theoretical Chemistry

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10.1021/ol101286a

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title = "Snap-top nanocarriers",

abstract = "(Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles. {\textcopyright} 2010 American Chemical Society.",

author = "Ambrogio, {Michael W.} and Pecorelli, {Travis A.} and Patel, {Kaushik I.} and Khashab, {Niveen M.} and Ali Trabolsi and Khatib, {Hussam A.} and Botros, {Youssry Y.} and Zink, {Jeffrey I.} and Stoddart, {Fraser Fraser Raser}",

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year = "2010",

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doi = "10.1021/ol101286a",

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journal = "Organic Letters",

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TY - JOUR

T1 - Snap-top nanocarriers

AU - Ambrogio, Michael W.

AU - Pecorelli, Travis A.

AU - Patel, Kaushik I.

AU - Khashab, Niveen M.

AU - Trabolsi, Ali

AU - Khatib, Hussam A.

AU - Botros, Youssry Y.

AU - Zink, Jeffrey I.

AU - Stoddart, Fraser Fraser Raser

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2010/8/6

Y1 - 2010/8/6

N2 - (Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles. © 2010 American Chemical Society.

AB - (Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles. © 2010 American Chemical Society.

UR - http://hdl.handle.net/10754/561502

UR - https://pubs.acs.org/doi/10.1021/ol101286a

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U2 - 10.1021/ol101286a

DO - 10.1021/ol101286a

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C2 - 20608669

SN - 1523-7060

VL - 12

SP - 3304

EP - 3307

JO - Organic Letters

JF - Organic Letters

IS - 15

ER -

Snap-top nanocarriers

Abstract

Bibliographical note

ASJC Scopus subject areas

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