Summary: SMotif is a server that identifies important structural segments or motifs for a given protein structure(s) based on conservation of both sequential as well as important structural features such as solvent inaccessibility, secondary structural content, hydrogen bonding pattern and residue packing. This server also provides three-dimensional orientation patterns of the identified motifs in terms of inter-motif distances and torsion angles. These motifs may form the common core and therefore, can also be employed to design and rationalize protein engineering and folding experiments.
Bibliographical noteFunding Information:
We thank Shameer Khadar for his help in installing the SMotif server. G.P. and P.N.S. acknowledge the financial support offered by the A*Star (Agency for Science, Technology and Research). S.C. acknowledges Intramural Research Program of the National Library of Medicine at NIH/DHHS. R.S. acknowledges National Centre for Biological Sciences (TIFR) for infrastructural support. Funding to pay the Open Access publication charges was provided by the Wellcome Trust, UK, as part of the Senior Research Fellowship of R.S.
ASJC Scopus subject areas
- Statistics and Probability
- Molecular Biology
- Computer Science Applications
- Computational Theory and Mathematics
- Computational Mathematics