Singlet Oxygen Generation via Two-Photon Excited FRET

William R. Dichtel; Jason M. Serin; Carine Edder; Jean M.J. Fréchet; Michael Matuszewski; Loon Seng Tan; Tymish Y. Ohulchanskyy; Paras N. Prasad

doi:10.1021/ja031647x

Singlet Oxygen Generation via Two-Photon Excited FRET

William R. Dichtel, Jason M. Serin, Carine Edder, Jean M.J. Fréchet^*, Michael Matuszewski, Loon Seng Tan, Tymish Y. Ohulchanskyy, Paras N. Prasad

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

232 Scopus citations

Abstract

A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.

Original language	English (US)
Pages (from-to)	5380-5381
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	17
DOIs	https://doi.org/10.1021/ja031647x
State	Published - May 5 2004
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja031647x

Cite this

@article{5eb37a433e334551b4005a9dc1a06d7d,

title = "Singlet Oxygen Generation via Two-Photon Excited FRET",

abstract = "A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.",

author = "Dichtel, {William R.} and Serin, {Jason M.} and Carine Edder and Fr{\'e}chet, {Jean M.J.} and Michael Matuszewski and Tan, {Loon Seng} and Ohulchanskyy, {Tymish Y.} and Prasad, {Paras N.}",

year = "2004",

month = may,

day = "5",

doi = "10.1021/ja031647x",

language = "English (US)",

volume = "126",

pages = "5380--5381",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "17",

}

TY - JOUR

T1 - Singlet Oxygen Generation via Two-Photon Excited FRET

AU - Dichtel, William R.

AU - Serin, Jason M.

AU - Edder, Carine

AU - Fréchet, Jean M.J.

AU - Matuszewski, Michael

AU - Tan, Loon Seng

AU - Ohulchanskyy, Tymish Y.

AU - Prasad, Paras N.

PY - 2004/5/5

Y1 - 2004/5/5

N2 - A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.

AB - A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.

UR - http://www.scopus.com/inward/record.url?scp=2342636314&partnerID=8YFLogxK

U2 - 10.1021/ja031647x

DO - 10.1021/ja031647x

M3 - Article

C2 - 15113208

AN - SCOPUS:2342636314

SN - 0002-7863

VL - 126

SP - 5380

EP - 5381

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 17

ER -

Singlet Oxygen Generation via Two-Photon Excited FRET

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this