Simultaneous identification of elastic properties, thickness, and diameter of arteries excited with ultrasound radiation force

Parikshit Dutta, Matthew W. Urban, Olivier P. Le Maître, James F. Greenleaf, Wilkins Aquino

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The elastic and geometric properties of arteries have been long recognized as important predictors of cardiovascular disease. This work presents a robust technique for the noninvasive characterization of anisotropic elastic properties as well as thickness and diameter in arterial vessels. In our approach, guided waves are excited along arteries using the radiation force of ultrasound. Group velocity is used as the quantity of interest to reconstruct elastic and geometric features of the vessels. One of the main contributions of this work is a systematic approach based on sparse-grid collocation interpolation to construct surrogate models of arteries. These surrogate models are in turn used with direct-search optimization techniques to produce fast and accurate estimates of elastic properties, diameter, and thickness. One of the attractive features of the proposed approach is that once a surrogate model is built, it can be used for near real-time identification across many different types of arteries. We demonstrate the feasibility of the method using simulated and in vitro laboratory experiments on a silicon rubber tube and a porcine carotid artery. Our results show that using our proposed method, we can reliably identify the longitudinal modulus, thickness, and diameter of arteries. The circumferential modulus was found to have little influence in the group velocity, which renders the former quantity unidentifiable using the current experimental setting. Future work will consider the measurement of circumferential waves with the objective of improving the identifiability of the circumferential modulus.

Original languageEnglish (US)
Pages (from-to)5279-5296
Number of pages18
JournalPhysics in Medicine and Biology
Issue number13
StatePublished - Jul 7 2015

Bibliographical note

Publisher Copyright:
© 2015 Institute of Physics and Engineering in Medicine.


  • Inverse problems
  • arteries
  • finite elements
  • surrogate models

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Simultaneous identification of elastic properties, thickness, and diameter of arteries excited with ultrasound radiation force'. Together they form a unique fingerprint.

Cite this