Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection

Christian Gaebler; Justin Dasilva; Eva Bednarski; Frauke Muecksch; Fabian Schmidt; Yiska Weisblum; Katrina G. Millard; Martina Turroja; Alice Cho; Zijun Wang; Marina Caskey; Michel C. Nussenzweig; Paul D. Bieniasz; Theodora Hatziioannou

doi:10.1093/ofid/ofac227

Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection

Christian Gaebler, Justin Dasilva, Eva Bednarski, Frauke Muecksch, Fabian Schmidt, Yiska Weisblum, Katrina G. Millard, Martina Turroja, Alice Cho, Zijun Wang, Marina Caskey, Michel C. Nussenzweig, Paul D. Bieniasz, Theodora Hatziioannou

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.

Original language	English (US)
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofac227
State	Published - Jul 1 2022
Externally published	Yes

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Generated from Scopus record by KAUST IRTS on 2023-02-15

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10.1093/ofid/ofac227

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Gaebler, C., Dasilva, J., Bednarski, E., Muecksch, F., Schmidt, F., Weisblum, Y., Millard, K. G., Turroja, M., Cho, A., Wang, Z., Caskey, M., Nussenzweig, M. C., Bieniasz, P. D., & Hatziioannou, T. (2022). Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection. Open Forum Infectious Diseases, 9(7). https://doi.org/10.1093/ofid/ofac227

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title = "Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection",

abstract = "The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.",

author = "Christian Gaebler and Justin Dasilva and Eva Bednarski and Frauke Muecksch and Fabian Schmidt and Yiska Weisblum and Millard, {Katrina G.} and Martina Turroja and Alice Cho and Zijun Wang and Marina Caskey and Nussenzweig, {Michel C.} and Bieniasz, {Paul D.} and Theodora Hatziioannou",

note = "Generated from Scopus record by KAUST IRTS on 2023-02-15",

year = "2022",

month = jul,

day = "1",

doi = "10.1093/ofid/ofac227",

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Gaebler, C, Dasilva, J, Bednarski, E, Muecksch, F, Schmidt, F, Weisblum, Y, Millard, KG, Turroja, M, Cho, A, Wang, Z, Caskey, M, Nussenzweig, MC, Bieniasz, PD & Hatziioannou, T 2022, 'Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection', Open Forum Infectious Diseases, vol. 9, no. 7. https://doi.org/10.1093/ofid/ofac227

TY - JOUR

T1 - Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection

AU - Gaebler, Christian

AU - Dasilva, Justin

AU - Bednarski, Eva

AU - Muecksch, Frauke

AU - Schmidt, Fabian

AU - Weisblum, Yiska

AU - Millard, Katrina G.

AU - Turroja, Martina

AU - Cho, Alice

AU - Wang, Zijun

AU - Caskey, Marina

AU - Nussenzweig, Michel C.

AU - Bieniasz, Paul D.

AU - Hatziioannou, Theodora

N1 - Generated from Scopus record by KAUST IRTS on 2023-02-15

PY - 2022/7/1

Y1 - 2022/7/1

N2 - The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.

AB - The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.

UR - https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofac227/6582237

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U2 - 10.1093/ofid/ofac227

DO - 10.1093/ofid/ofac227

M3 - Article

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SN - 2328-8957

VL - 9

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 7

ER -

Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection

Abstract

Bibliographical note

UN SDGs

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