Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Oliver Glass; Ricardo Henao; Keyur Patel; Cynthia D. Guy; Hans J. Gruss; Wing Kin Syn; Cynthia A. Moylan; Robert Streilein; Russell Hall; Anna Mae Diehl; Manal F. Abdelmalek

doi:10.1002/hep4.1237

Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Oliver Glass, Ricardo Henao, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Wing Kin Syn, Cynthia A. Moylan, Robert Streilein, Russell Hall, Anna Mae Diehl, Manal F. Abdelmalek

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

The severity of hepatic fibrosis is the primary predictor of liver-related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD-associated fibrosis are limited. We analyzed baseline serum samples for 24 cytokines of 97 patients with biopsy-proven NAFLD. These patients were prospectively enrolled in a clinical study (ClinicalTrials.gov NCT00794716) to identify cytokines associated with liver fibrosis in patients with nonalcoholic steatohepatitis. Patients were stratified according to severity of hepatic fibrosis (mild, stage 0-1, n = 37; moderate, stage 2, n = 40; and advanced, stage 3-4, n = 20) while controlling for age, race, sex, body mass index, and diabetes mellitus. Interleukin-8 (IL-8), osteopontin (OPN), and monocyte chemoattractant protein 1 (MCP1) were associated with liver fibrosis (P

Original language	English (US)
Pages (from-to)	1344-1355
Number of pages	12
Journal	Hepatology Communications
Volume	2
Issue number	11
DOIs	https://doi.org/10.1002/hep4.1237
State	Published - Nov 1 2018
Externally published	Yes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-02-15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/hep4.1237

Cite this

Glass, O., Henao, R., Patel, K., Guy, C. D., Gruss, H. J., Syn, W. K., Moylan, C. A., Streilein, R., Hall, R., Mae Diehl, A., & Abdelmalek, M. F. (2018). Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Hepatology Communications, 2(11), 1344-1355. https://doi.org/10.1002/hep4.1237

@article{3ba8b0160575440e99c81cbbcf8601a1,

title = "Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease",

abstract = "The severity of hepatic fibrosis is the primary predictor of liver-related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD-associated fibrosis are limited. We analyzed baseline serum samples for 24 cytokines of 97 patients with biopsy-proven NAFLD. These patients were prospectively enrolled in a clinical study (ClinicalTrials.gov NCT00794716) to identify cytokines associated with liver fibrosis in patients with nonalcoholic steatohepatitis. Patients were stratified according to severity of hepatic fibrosis (mild, stage 0-1, n = 37; moderate, stage 2, n = 40; and advanced, stage 3-4, n = 20) while controlling for age, race, sex, body mass index, and diabetes mellitus. Interleukin-8 (IL-8), osteopontin (OPN), and monocyte chemoattractant protein 1 (MCP1) were associated with liver fibrosis (P",

author = "Oliver Glass and Ricardo Henao and Keyur Patel and Guy, {Cynthia D.} and Gruss, {Hans J.} and Syn, {Wing Kin} and Moylan, {Cynthia A.} and Robert Streilein and Russell Hall and {Mae Diehl}, Anna and Abdelmalek, {Manal F.}",

note = "Generated from Scopus record by KAUST IRTS on 2023-02-15",

year = "2018",

month = nov,

day = "1",

doi = "10.1002/hep4.1237",

language = "English (US)",

volume = "2",

pages = "1344--1355",

journal = "Hepatology Communications",

issn = "2471-254X",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

Glass, O, Henao, R, Patel, K, Guy, CD, Gruss, HJ, Syn, WK, Moylan, CA, Streilein, R, Hall, R, Mae Diehl, A & Abdelmalek, MF 2018, 'Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease', Hepatology Communications, vol. 2, no. 11, pp. 1344-1355. https://doi.org/10.1002/hep4.1237

TY - JOUR

T1 - Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

AU - Glass, Oliver

AU - Henao, Ricardo

AU - Patel, Keyur

AU - Guy, Cynthia D.

AU - Gruss, Hans J.

AU - Syn, Wing Kin

AU - Moylan, Cynthia A.

AU - Streilein, Robert

AU - Hall, Russell

AU - Mae Diehl, Anna

AU - Abdelmalek, Manal F.

N1 - Generated from Scopus record by KAUST IRTS on 2023-02-15

PY - 2018/11/1

Y1 - 2018/11/1

N2 - The severity of hepatic fibrosis is the primary predictor of liver-related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD-associated fibrosis are limited. We analyzed baseline serum samples for 24 cytokines of 97 patients with biopsy-proven NAFLD. These patients were prospectively enrolled in a clinical study (ClinicalTrials.gov NCT00794716) to identify cytokines associated with liver fibrosis in patients with nonalcoholic steatohepatitis. Patients were stratified according to severity of hepatic fibrosis (mild, stage 0-1, n = 37; moderate, stage 2, n = 40; and advanced, stage 3-4, n = 20) while controlling for age, race, sex, body mass index, and diabetes mellitus. Interleukin-8 (IL-8), osteopontin (OPN), and monocyte chemoattractant protein 1 (MCP1) were associated with liver fibrosis (P

AB - The severity of hepatic fibrosis is the primary predictor of liver-related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD-associated fibrosis are limited. We analyzed baseline serum samples for 24 cytokines of 97 patients with biopsy-proven NAFLD. These patients were prospectively enrolled in a clinical study (ClinicalTrials.gov NCT00794716) to identify cytokines associated with liver fibrosis in patients with nonalcoholic steatohepatitis. Patients were stratified according to severity of hepatic fibrosis (mild, stage 0-1, n = 37; moderate, stage 2, n = 40; and advanced, stage 3-4, n = 20) while controlling for age, race, sex, body mass index, and diabetes mellitus. Interleukin-8 (IL-8), osteopontin (OPN), and monocyte chemoattractant protein 1 (MCP1) were associated with liver fibrosis (P

UR - https://onlinelibrary.wiley.com/doi/10.1002/hep4.1237

UR - http://www.scopus.com/inward/record.url?scp=85062962139&partnerID=8YFLogxK

U2 - 10.1002/hep4.1237

DO - 10.1002/hep4.1237

M3 - Article

SN - 2471-254X

VL - 2

SP - 1344

EP - 1355

JO - Hepatology Communications

JF - Hepatology Communications

IS - 11

ER -

Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this