Sequential transfer of left-right information during vertebrate embryo development

Ángel Raya; Juan Carlos Izpisúa Belmonte

doi:10.1016/j.gde.2004.07.011

Sequential transfer of left-right information during vertebrate embryo development

Ángel Raya, Juan Carlos Izpisúa Belmonte

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.

Original language	English (US)
Pages (from-to)	575-581
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/j.gde.2004.07.011
State	Published - Oct 2004
Externally published	Yes

Bibliographical note

Funding Information:
The authors are indebted to all the members of the laboratory for fruitful discussions, and to May-Fun Schwarz for help in the preparation of this manuscript. The research on left-right asymmetry in our laboratory is supported by the NIH, American Heart Association, and G. Harold and Leila Y. Mathers Charitable Foundation.

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2004.07.011

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title = "Sequential transfer of left-right information during vertebrate embryo development",

abstract = "The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.",

author = "{\'A}ngel Raya and Belmonte, {Juan Carlos Izpis{\'u}a}",

note = "Funding Information: The authors are indebted to all the members of the laboratory for fruitful discussions, and to May-Fun Schwarz for help in the preparation of this manuscript. The research on left-right asymmetry in our laboratory is supported by the NIH, American Heart Association, and G. Harold and Leila Y. Mathers Charitable Foundation.",

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AU - Belmonte, Juan Carlos Izpisúa

N1 - Funding Information: The authors are indebted to all the members of the laboratory for fruitful discussions, and to May-Fun Schwarz for help in the preparation of this manuscript. The research on left-right asymmetry in our laboratory is supported by the NIH, American Heart Association, and G. Harold and Leila Y. Mathers Charitable Foundation.

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N2 - The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.

AB - The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.

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DO - 10.1016/j.gde.2004.07.011

M3 - Review article

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AN - SCOPUS:5444229981

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JO - Current Opinion in Genetics and Development

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IS - 5

ER -

Sequential transfer of left-right information during vertebrate embryo development

Abstract

Bibliographical note

ASJC Scopus subject areas

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