Sequential transfer of left-right information during vertebrate embryo development

Ángel Raya, Juan Carlos Izpisúa Belmonte

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.

Original languageEnglish (US)
Pages (from-to)575-581
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number5
StatePublished - Oct 2004
Externally publishedYes

Bibliographical note

Funding Information:
The authors are indebted to all the members of the laboratory for fruitful discussions, and to May-Fun Schwarz for help in the preparation of this manuscript. The research on left-right asymmetry in our laboratory is supported by the NIH, American Heart Association, and G. Harold and Leila Y. Mathers Charitable Foundation.

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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