TY - JOUR
T1 - Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill
AU - Tsujimoto, Hajime
AU - Hasegawa, Akira
AU - Maki, Noboru
AU - Fukasawa, Masashi
AU - Miura, Tomoyuki
AU - Speidel, Stephan
AU - Cooper, Robert W.
AU - Moriyama, Etsuko N.
AU - Gojobori, Takashi
AU - Hayami, Masanori
PY - 1989
Y1 - 1989
N2 - SINCE the isolation of an HIV-2-related virus from captive macaques (SIVMAC), the origin of human immunodeficiency viruses, a much debated subject, has been attributed to monkeys. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVSM), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.
AB - SINCE the isolation of an HIV-2-related virus from captive macaques (SIVMAC), the origin of human immunodeficiency viruses, a much debated subject, has been attributed to monkeys. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVSM), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.
UR - http://www.scopus.com/inward/record.url?scp=0024442974&partnerID=8YFLogxK
U2 - 10.1038/341539a0
DO - 10.1038/341539a0
M3 - Article
C2 - 2797181
AN - SCOPUS:0024442974
SN - 0028-0836
VL - 341
SP - 539
EP - 541
JO - NATURE
JF - NATURE
IS - 6242
ER -
