Separation of Nanoparticles in Aqueous Multiphase Systems through Centrifugation

Ozge Akbulut, Charles R. Mace, Ramses V. Martinez, Ashok A. Kumar, Zhihong Nie, Matthew R. Patton, George M. Whitesides

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This paper demonstrates the use of aqueous multiphase systems (MuPSs) as media for rate-zonal centrifugation to separate nanoparticles of different shapes and sizes. The properties of MuPSs do not change with time or during centrifugation; this stability facilitates sample collection after separation. A three-phase system demonstrates the separation of the reaction products (nanorods, nanospheres, and large particles) of a synthesis of gold nanorods, and enriches the nanorods from 48 to 99% in less than ten minutes using a benchtop centrifuge. © 2012 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)4060-4064
Number of pages5
JournalNano Letters
Issue number8
StatePublished - Jul 6 2012
Externally publishedYes

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