TY - GEN
T1 - Sensors and Instrumentation towards early detection of osteoporosis
AU - Afsarimanesh, Nasrin
AU - Mukhopadhyay, Subhas C
AU - Kruger, Marlena
AU - Yu, Pak-Lam
AU - Kosel, Jürgen
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2016/7/27
Y1 - 2016/7/27
N2 - A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems. © 2016 IEEE.
AB - A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems. © 2016 IEEE.
UR - http://hdl.handle.net/10754/621291
UR - http://ieeexplore.ieee.org/document/7520573/
UR - http://www.scopus.com/inward/record.url?scp=84980332206&partnerID=8YFLogxK
U2 - 10.1109/I2MTC.2016.7520573
DO - 10.1109/I2MTC.2016.7520573
M3 - Conference contribution
SN - 9781467392204
BT - 2016 IEEE International Instrumentation and Measurement Technology Conference Proceedings
PB - Institute of Electrical and Electronics Engineers (IEEE)
ER -