Sensors and Instrumentation towards early detection of osteoporosis

Nasrin Afsarimanesh, Subhas C Mukhopadhyay, Marlena Kruger, Pak-Lam Yu, Jürgen Kosel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems. © 2016 IEEE.
Original languageEnglish (US)
Title of host publication2016 IEEE International Instrumentation and Measurement Technology Conference Proceedings
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
ISBN (Print)9781467392204
StatePublished - Jul 27 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01


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