Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.

Jinqiao Dong; Yutong Pan; Heng Wang; Kuiwei Yang; Lingmei Liu; Zhiwei Qiao; Yi Di Yuan; Shing Bo Peh; Jian Zhang; Leilei Shi; Hong Liang; Yu Han; Xiaopeng Li; Jianwen Jiang; Bin Liu; Dan Zhao

doi:10.1002/anie.201915199

Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.

Jinqiao Dong, Yutong Pan, Heng Wang, Kuiwei Yang, Lingmei Liu, Zhiwei Qiao, Yi Di Yuan, Shing Bo Peh, Jian Zhang, Leilei Shi, Hong Liang, Yu Han, Xiaopeng Li, Jianwen Jiang, Bin Liu, Dan Zhao

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Abstract

The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.

Original language	English (US)
Journal	Angewandte Chemie (International ed. in English)
DOIs	https://doi.org/10.1002/anie.201915199
State	Published - Jan 23 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the National Research Founda-tion Singapore (NRF2018-NRF-ANR007 POCEMON), theMinistry of Education—Singapore (MOE AcRF Tier 1 R-279-000-540-114, R-279-000-482-133, Tier 2 MOE2018-T2-2-148), the Agency for Science, Technology and Research (IRGA1783c0015, IAF-PP A1789a0024), National Natural ScienceFoundation of China (No. 21676094 and 21576058), Funda-mental Research Funds for the Central Universities(2017MS083), and the technical support from NationalSupercomputer Center in Guangzhou (Tianhe-2).

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Dong, J., Pan, Y., Wang, H., Yang, K., Liu, L., Qiao, Z., Di Yuan, Y., Peh, S. B., Zhang, J., Shi, L., Liang, H., Han, Y., Li, X., Jiang, J., Liu, B., & Zhao, D. (2020). Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging. Angewandte Chemie (International ed. in English). https://doi.org/10.1002/anie.201915199

@article{5d32553091994b96b9b8dd881c614fb5,

title = "Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.",

abstract = "The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.",

author = "Jinqiao Dong and Yutong Pan and Heng Wang and Kuiwei Yang and Lingmei Liu and Zhiwei Qiao and {Di Yuan}, Yi and Peh, {Shing Bo} and Jian Zhang and Leilei Shi and Hong Liang and Yu Han and Xiaopeng Li and Jianwen Jiang and Bin Liu and Dan Zhao",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the National Research Founda-tion Singapore (NRF2018-NRF-ANR007 POCEMON), theMinistry of Education—Singapore (MOE AcRF Tier 1 R-279-000-540-114, R-279-000-482-133, Tier 2 MOE2018-T2-2-148), the Agency for Science, Technology and Research (IRGA1783c0015, IAF-PP A1789a0024), National Natural ScienceFoundation of China (No. 21676094 and 21576058), Funda-mental Research Funds for the Central Universities(2017MS083), and the technical support from NationalSupercomputer Center in Guangzhou (Tianhe-2).",

year = "2020",

month = jan,

day = "23",

doi = "10.1002/anie.201915199",

language = "English (US)",

journal = "Angewandte Chemie (International ed. in English)",

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Dong, J, Pan, Y, Wang, H, Yang, K, Liu, L, Qiao, Z, Di Yuan, Y, Peh, SB, Zhang, J, Shi, L, Liang, H, Han, Y, Li, X, Jiang, J, Liu, B & Zhao, D 2020, 'Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.', Angewandte Chemie (International ed. in English). https://doi.org/10.1002/anie.201915199

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T1 - Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.

AU - Dong, Jinqiao

AU - Pan, Yutong

AU - Wang, Heng

AU - Yang, Kuiwei

AU - Liu, Lingmei

AU - Qiao, Zhiwei

AU - Di Yuan, Yi

AU - Peh, Shing Bo

AU - Zhang, Jian

AU - Shi, Leilei

AU - Liang, Hong

AU - Han, Yu

AU - Li, Xiaopeng

AU - Jiang, Jianwen

AU - Liu, Bin

AU - Zhao, Dan

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the National Research Founda-tion Singapore (NRF2018-NRF-ANR007 POCEMON), theMinistry of Education—Singapore (MOE AcRF Tier 1 R-279-000-540-114, R-279-000-482-133, Tier 2 MOE2018-T2-2-148), the Agency for Science, Technology and Research (IRGA1783c0015, IAF-PP A1789a0024), National Natural ScienceFoundation of China (No. 21676094 and 21576058), Funda-mental Research Funds for the Central Universities(2017MS083), and the technical support from NationalSupercomputer Center in Guangzhou (Tianhe-2).

PY - 2020/1/23

Y1 - 2020/1/23

N2 - The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.

AB - The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.

UR - http://hdl.handle.net/10754/661343

UR - http://doi.wiley.com/10.1002/anie.201915199

UR - http://www.scopus.com/inward/record.url?scp=85078665289&partnerID=8YFLogxK

U2 - 10.1002/anie.201915199

DO - 10.1002/anie.201915199

M3 - Article

C2 - 31859381

SN - 1433-7851

JO - Angewandte Chemie (International ed. in English)

JF - Angewandte Chemie (International ed. in English)

ER -

Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.

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