Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.

Jinqiao Dong, Yutong Pan, Heng Wang, Kuiwei Yang, Lingmei Liu, Zhiwei Qiao, Yi Di Yuan, Shing Bo Peh, Jian Zhang, Leilei Shi, Hong Liang, Yu Han, Xiaopeng Li, Jianwen Jiang, Bin Liu, Dan Zhao

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99 Scopus citations

Abstract

The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.
Original languageEnglish (US)
JournalAngewandte Chemie (International ed. in English)
DOIs
StatePublished - Jan 23 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the National Research Founda-tion Singapore (NRF2018-NRF-ANR007 POCEMON), theMinistry of Education—Singapore (MOE AcRF Tier 1 R-279-000-540-114, R-279-000-482-133, Tier 2 MOE2018-T2-2-148), the Agency for Science, Technology and Research (IRGA1783c0015, IAF-PP A1789a0024), National Natural ScienceFoundation of China (No. 21676094 and 21576058), Funda-mental Research Funds for the Central Universities(2017MS083), and the technical support from NationalSupercomputer Center in Guangzhou (Tianhe-2).

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