Self-assembly behavior of well-defined polymethylene-block-poly(ethylene glycol) copolymers in aqueous solution

Nazeeha Alkayal, Georgios Zapsas, Panagiotis Bilalis, Nikos Hadjichristidis

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A series of well-defined amphiphilic polymethylene-b-poly(ethylene glycol) (PM-b-PEG) diblock copolymers, with different hydrophobic chain length, were synthesized by combining Diels-Alder reaction with polyhomologation. The successful synthetic procedure was confirmed by size-exclusion chromatography (SEC) and 1H NMR spectroscopy. These block copolymers self-assembled into spherical micelles in aqueous solutions and exhibit low critical micelle concentration (CMC) of 2–4 mg/mL, as determined by fluorescence spectroscopy using pyrene as a probe. Measurements of the micelle hydrodynamic diameters, performed by dynamic light scattering (DLS), cryo-transmission electron microscopy (cryo-TEM) and atomic force microscopy (AFM), revealed a direct dependence of the micelle size from the polymethylene block length.
Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
StatePublished - Sep 22 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Research reported in this publication supported by King Abdullah University of Science and Technology. The assistance of Dr Rachid Sougrat, KAUST Advanced Nanofabrication Imaging and Characterization Core Laboratory, in cryo-TEM experiments is gratefully acknowledged.


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