Self-assembling tetrameric peptides allow in situ 3D bioprinting under physiological conditions

Sakandar Rauf, Hepi Hari Susapto, Kowther Kahin, Salwa Alshehi, Sherin Abdelrahman, Jordy Homing Lam, Sultan Asad, Sandip Jadhav, Dhakshinamoorthy Sundaramurthi, Xin Gao, Charlotte Hauser

Research output: Contribution to journalArticlepeer-review


We have developed an in situ bioprinting method that allows printing of cells under true physiological conditions applying self-assembling ultrashort peptides as bioinks. This method avoids cell stressing methods such as UV-treatment, chemical crosslinking and viscous bioinks printing methods. We further demonstrate that different nanomaterials can easily be synthesized or incorporated in the 3D bioprinted peptide scaffolds which open up the possibility of functionalized 3D scaffolds.
Original languageEnglish (US)
JournalAccepted by Journal of Materials Chemistry B
StatePublished - 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-12-19
Acknowledgements: The work was supported by funding from King Abdullah University of Science and Technology (KAUST). Synthesis of IVFK and IVZK peptides was first performed at the Institute of Bioengineering and Nanotechnology, A*Star, Singapore. The authors would like to acknowledge Prof. Takashi Gojobori, Hajime Ohyanagi and Dr. Katsuhiko Mineta for providing help in analyzing the RNA sequencing data. Visiting student and scholarship holder from the Studienstiftung des deutschen Volkes Ms. Annemarie Kehl, Georg-August University Goettingen, Germany, kindly measured the CD spectra. The authors would like to acknowledge KAUST’s Core Labs for supporting the sequencing and microscopy analysis.


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