Self-Assembled Metal–Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

Safa'a Al-Rehili; Mram Z. Alyami; Yang Zhang; Basem Moosa; Peng Yang; Kholod Alamoudi; Siba Alharbi; Ohoud Alharbi; Rachid Sougrat; Abdulaziz AlMalik; Niveen M. Khashab

doi:10.1021/acsabm.8b00720

Self-Assembled Metal–Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

Safa'a Al-Rehili, Mram Z. Alyami, Yang Zhang, Basem Moosa, Peng Yang, Kholod Alamoudi, Siba Alharbi, Ohoud Alharbi, Rachid Sougrat, Abdulaziz AlMalik, Niveen M. Khashab

Research output: Contribution to journal › Article › peer-review

Abstract

Natural and synthetic membrane active molecules increase the permeability of cell membranes. This can help cells combat multidrug efflux pumps as well as improve signaling and transfection. In this work, thermoresponsive metal–organic complexes (MOCs) have been constructed to transport cell impermeable cargo across the membrane through a pore-aiding assembly. These MOCs can be reversibly controlled as they collapse when the temperature is increased and are simultaneously regenerated when the system is cooled down to room temperature. These ON/OFF molecular valves can be potentially used to overcome multidrug resistance (MDR) in cancer cells and as building blocks for artificial cells.

Original language	English (US)
Pages (from-to)	970-974
Number of pages	5
Journal	ACS Applied Bio Materials
Volume	2
Issue number	3
DOIs	https://doi.org/10.1021/acsabm.8b00720
State	Published - Feb 6 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by King Abdullah University of Science and Technology (KAUST). Scheme 1 and the TOC illustration were produced by Xavier Pita, scientific illustrator at King Abdullah University of Science and Technology (KAUST).

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10.1021/acsabm.8b00720

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title = "Self-Assembled Metal–Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes",

abstract = "Natural and synthetic membrane active molecules increase the permeability of cell membranes. This can help cells combat multidrug efflux pumps as well as improve signaling and transfection. In this work, thermoresponsive metal–organic complexes (MOCs) have been constructed to transport cell impermeable cargo across the membrane through a pore-aiding assembly. These MOCs can be reversibly controlled as they collapse when the temperature is increased and are simultaneously regenerated when the system is cooled down to room temperature. These ON/OFF molecular valves can be potentially used to overcome multidrug resistance (MDR) in cancer cells and as building blocks for artificial cells.",

author = "Safa'a Al-Rehili and Alyami, {Mram Z.} and Yang Zhang and Basem Moosa and Peng Yang and Kholod Alamoudi and Siba Alharbi and Ohoud Alharbi and Rachid Sougrat and Abdulaziz AlMalik and Khashab, {Niveen M.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by King Abdullah University of Science and Technology (KAUST). Scheme 1 and the TOC illustration were produced by Xavier Pita, scientific illustrator at King Abdullah University of Science and Technology (KAUST).",

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doi = "10.1021/acsabm.8b00720",

language = "English (US)",

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T1 - Self-Assembled Metal–Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

AU - Al-Rehili, Safa'a

AU - Alyami, Mram Z.

AU - Zhang, Yang

AU - Moosa, Basem

AU - Yang, Peng

AU - Alamoudi, Kholod

AU - Alharbi, Siba

AU - Alharbi, Ohoud

AU - Sougrat, Rachid

AU - AlMalik, Abdulaziz

AU - Khashab, Niveen M.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by King Abdullah University of Science and Technology (KAUST). Scheme 1 and the TOC illustration were produced by Xavier Pita, scientific illustrator at King Abdullah University of Science and Technology (KAUST).

PY - 2019/2/6

Y1 - 2019/2/6

N2 - Natural and synthetic membrane active molecules increase the permeability of cell membranes. This can help cells combat multidrug efflux pumps as well as improve signaling and transfection. In this work, thermoresponsive metal–organic complexes (MOCs) have been constructed to transport cell impermeable cargo across the membrane through a pore-aiding assembly. These MOCs can be reversibly controlled as they collapse when the temperature is increased and are simultaneously regenerated when the system is cooled down to room temperature. These ON/OFF molecular valves can be potentially used to overcome multidrug resistance (MDR) in cancer cells and as building blocks for artificial cells.

AB - Natural and synthetic membrane active molecules increase the permeability of cell membranes. This can help cells combat multidrug efflux pumps as well as improve signaling and transfection. In this work, thermoresponsive metal–organic complexes (MOCs) have been constructed to transport cell impermeable cargo across the membrane through a pore-aiding assembly. These MOCs can be reversibly controlled as they collapse when the temperature is increased and are simultaneously regenerated when the system is cooled down to room temperature. These ON/OFF molecular valves can be potentially used to overcome multidrug resistance (MDR) in cancer cells and as building blocks for artificial cells.

UR - http://hdl.handle.net/10754/655985

UR - http://pubs.acs.org/doi/10.1021/acsabm.8b00720

UR - http://www.scopus.com/inward/record.url?scp=85072838481&partnerID=8YFLogxK

U2 - 10.1021/acsabm.8b00720

DO - 10.1021/acsabm.8b00720

M3 - Article

SN - 2576-6422

VL - 2

SP - 970

EP - 974

JO - ACS Applied Bio Materials

JF - ACS Applied Bio Materials

IS - 3

ER -

Self-Assembled Metal–Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

Abstract

Bibliographical note

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