Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

Yuanyuan Huang, Xin Fang, Xiaoxi Lin, Huaifeng Li, Weiming He, Kuo-Wei Huang, Yaofeng Yuan, Zhiqiang Weng

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups. © 2012 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)9949-9953
Number of pages5
Issue number48
StatePublished - Dec 2012

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We acknowledge the financial support from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W. and King Abdullah University of Science and Technology to K.-W.H.

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery


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