Abstract
An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups. © 2012 Elsevier Ltd. All rights reserved.
Original language | English (US) |
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Pages (from-to) | 9949-9953 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 68 |
Issue number | 48 |
DOIs | |
State | Published - Dec 2012 |
Bibliographical note
KAUST Repository Item: Exported on 2020-10-01Acknowledgements: We acknowledge the financial support from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W. and King Abdullah University of Science and Technology to K.-W.H.
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery