Cellular fate is determined by transcriptional networks and epigenetic states. In addition to protein factors, noncoding RNAs (ncRNAs), particularly microRNAs and long ncRNAs, are able to remodel transcriptional circuits and reshape epigenetic landscapes. Here we draw upon recent findings to discuss the emerging roles of these ncRNAs in cellular reprogramming, transdifferentiation and organ regeneration.
|Original language||English (US)|
|Number of pages||3|
|Journal||Nature Structural and Molecular Biology|
|State||Published - Jan 1 2015|
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology