Role of miRNAs and siRNAs in biotic and abiotic stress responses of plants

Basel Khraiwesh, Jian-Kang Zhu, Jianhua Zhu

Research output: Contribution to journalArticlepeer-review

876 Scopus citations


Small, non-coding RNAs are a distinct class of regulatory RNAs in plants and animals that control a variety of biological processes. In plants, several classes of small RNAs with specific sizes and dedicated functions have evolved through a series of pathways. The major classes of small RNAs include microRNAs (miRNAs) and small interfering RNAs (siRNAs), which differ in their biogenesis. miRNAs control the expression of cognate target genes by binding to reverse complementary sequences, resulting in cleavage or translational inhibition of the target RNAs. siRNAs have a similar structure, function, and biogenesis as miRNAs but are derived from long double-stranded RNAs and can often direct DNA methylation at target sequences. Besides their roles in growth and development and maintenance of genome integrity, small RNAs are also important components in plant stress responses. One way in which plants respond to environmental stress is by modifying their gene expression through the activity of small RNAs. Thus, understanding how small RNAs regulate gene expression will enable researchers to explore the role of small RNAs in biotic and abiotic stress responses. This review focuses on the regulatory roles of plant small RNAs in the adaptive response to stresses. This article is part of a Special Issue entitled: Plant gene regulation in response to abiotic stress. © 2011 Elsevier B.V.
Original languageEnglish (US)
Pages (from-to)137-148
Number of pages12
JournalBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Issue number2
StatePublished - May 20 2011

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by USDA and NIH grants to J.-K. Zhu and by National Science Foundation grants IOS0919745 and MCB0950242 to J. Zhu.

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics
  • Molecular Biology
  • Biophysics


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