Role of activity-dependent regulation of neuronal chloride homeostasis in development

Hubert Fiumelli*, Melanie A. Woodin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations


The polarity of neurotransmission mediated by the γ-amino butyric acid (GABA) type A receptor depends crucially on intracellular chloride concentration, which is largely determined by the expression and function of cation/chloride co-transporters. Recent evidence shows how both activity and neurotrophic factors can affect GABAergic transmission in the mammalian central nervous system through their effects on the neuron-specific chloride-extruding transporter KCC2. In particular, GABAergic neurotransmission early in development, sustained neuronal activity in mature networks and brain-derived neurotrophic factor each modulate the expression or function of KCC2. The resulting changes in intracellular chloride concentration alter the nature or strength of fast GABAergic neurotransmission, profoundly affecting the development and function of neuronal networks.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalCurrent Opinion in Neurobiology
Issue number1
StatePublished - Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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