Retrotransposons and non-protein coding RNAs

Tobias Mourier; Eske Willerslev

doi:10.1093/bfgp/elp036

Retrotransposons and non-protein coding RNAs

Tobias Mourier^*, Eske Willerslev

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Retrotransposons constitute a significant fraction of mammalian genomes. Considering the finding of widespread transcriptional activity across entire genomes, it is not surprising that retrotransposons contribute to the collective RNA pool. However, the transcriptional output from retrotransposons does not merely represent spurious transcription. We review examples of functional RNAs transcribed from retrotransposons, and address the collection of non-protein coding RNAs derived from transposable element sequences, including numerous human microRNAs and the neuronal BC RNAs. Finally, we review the emerging understanding of how retrotransposons themselves are regulated by small RNAs.

Original language	English (US)
Article number	elp036
Pages (from-to)	493-501
Number of pages	9
Journal	Briefings in Functional Genomics and Proteomics
Volume	8
Issue number	6
DOIs	https://doi.org/10.1093/bfgp/elp036
State	Published - Sep 3 2009
Externally published	Yes

Keywords

Gene regulation
RNA genes
Transposable elements

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.1093/bfgp/elp036

Cite this

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AB - Retrotransposons constitute a significant fraction of mammalian genomes. Considering the finding of widespread transcriptional activity across entire genomes, it is not surprising that retrotransposons contribute to the collective RNA pool. However, the transcriptional output from retrotransposons does not merely represent spurious transcription. We review examples of functional RNAs transcribed from retrotransposons, and address the collection of non-protein coding RNAs derived from transposable element sequences, including numerous human microRNAs and the neuronal BC RNAs. Finally, we review the emerging understanding of how retrotransposons themselves are regulated by small RNAs.

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KW - Transposable elements

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Retrotransposons and non-protein coding RNAs

Abstract

Keywords

ASJC Scopus subject areas

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