Reprogramming toward heart regeneration: Stem cells and beyond

Aitor Aguirre, Ignacio Sancho-Martinez, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


Finding a cure for cardiovascular disease remains a major unmet medical need. Recent investigations have started to unveil the mechanisms of mammalian heart regeneration. The study of the regenerative mechanisms in lower vertebrate and mammalian animal models has provided clues for the experimental activation of proregenerative responses in the heart. In parallel, the use of endogenous adult stem cell populations alongside the recent application of reprogramming technologies has created major expectations for the development of therapies targeting heart disease. Together, these new approaches are bringing us closer to more successful strategies for the treatment of heart disease.

Original languageEnglish (US)
Pages (from-to)275-284
Number of pages10
JournalCell Stem Cell
Issue number3
StatePublished - Mar 7 2013
Externally publishedYes

Bibliographical note

Funding Information:
We would first like to apologize to all those authors whose outstanding work could not be cited due to space constraints. We thank all members of the Izpisua Belmonte laboratory for critical discussion. I.S.-M. was partially supported by a Nomis Foundation Fellowship. Work in the laboratory of J.C.I.B. was supported by TERCEL-ISCIII-MINECO, CIBER, Fundacion Cellex, G. Harold and Leila Y. Mathers Charitable Foundation, and The Leona M. and Harry B. Helmsley Charitable Trust.

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology


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