TY - JOUR
T1 - Relationship between intracortical electrode design and chronic recording function
AU - Karumbaiah, Lohitash
AU - Saxena, Tarun
AU - Carlson, David
AU - Patil, Ketki
AU - Patkar, Radhika
AU - Gaupp, Eric A.
AU - Betancur, Martha
AU - Stanley, Garrett B.
AU - Carin, Lawrence
AU - Bellamkonda, Ravi V.
N1 - Generated from Scopus record by KAUST IRTS on 2021-02-09
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Intracortical electrodes record neural signals directly from local populations of neurons in the brain, and conduct them to external electronics that control prosthetics. However, the relationship between electrode design, defined by shape, size and tethering; and long-term (chronic) stability of the neuron-electrode interface is poorly understood. Here, we studied the effects of various commercially available intracortical electrode designs that vary in shape (cylindrical, planar), size (15μm, 50μm and 75μm), and tethering [electrode connections to connector with (tethered) and without tethering cable (untethered)] using histological, transcriptomic, and electrophysiological analyses over acute (3 day) and chronic (12 week) timepoints. Quantitative analysis of histological sections indicated that Michigan 50μm (M50) and Michigan tethered (MT) electrodes induced significantly (p
AB - Intracortical electrodes record neural signals directly from local populations of neurons in the brain, and conduct them to external electronics that control prosthetics. However, the relationship between electrode design, defined by shape, size and tethering; and long-term (chronic) stability of the neuron-electrode interface is poorly understood. Here, we studied the effects of various commercially available intracortical electrode designs that vary in shape (cylindrical, planar), size (15μm, 50μm and 75μm), and tethering [electrode connections to connector with (tethered) and without tethering cable (untethered)] using histological, transcriptomic, and electrophysiological analyses over acute (3 day) and chronic (12 week) timepoints. Quantitative analysis of histological sections indicated that Michigan 50μm (M50) and Michigan tethered (MT) electrodes induced significantly (p
UR - https://linkinghub.elsevier.com/retrieve/pii/S0142961213007989
UR - http://www.scopus.com/inward/record.url?scp=84881662306&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2013.07.016
DO - 10.1016/j.biomaterials.2013.07.016
M3 - Article
SN - 0142-9612
VL - 34
SP - 8061
EP - 8074
JO - Biomaterials
JF - Biomaterials
IS - 33
ER -