Reinforcement of alginate-gelatin hydrogels with bioceramics for biomedical applications: A comparative study

Alan Avila-Ramirez, Kevin Catzim-Ríos, Carlos Enrique Guerrero-Beltrán, Erick Ramírez-Cedillo, Wendy Ortega-Lara

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


This study states the preparation of novel ink with potential use for bone and cartilage tissue restoration. 3Dprint manufacturing allows customizing prostheses and complex morphologies of any traumatism. The quest for bioinks that increase the restoration rate based on printable polymers is a need. This study is focused on main steps, the synthesis of two bioceramic materials as WO3 and Na2Ti6O13, its integration into a biopolymeric-base matrix of Alginate and Gelatin to support the particles in a complete scaffold to trigger the potential nucleation of crystals of calcium phosphates, and its comparative study with independent systems of formulations with bioceramic particles as Al2O3, TiO2, and ZrO2 . FT-IR and SEM studies result in hydroxyapatite’s potential nucleation, which can generate bone or cartilage tissue regeneration systems with low or null cytotoxicity. These composites were tested by cell culture techniques to assess their biocompatibility. Moreover, the reinforcement was compared individually by mechanical tests with higher results on synthesized materials Na2Ti6O13 with 35 kPa and WO3 with 63 kPa. Finally, the integration of these composite materials formulated by Alginate/Gelatin and bioceramic has been characterized as functional for further manufacturing with the aid of novel biofabrication techniques such as 3D printing.
Original languageEnglish (US)
Pages (from-to)184
Issue number4
StatePublished - Oct 26 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-11-11
Acknowledgements: This research was funded by Tecnologico de Monterrey through the Research Group of Nano-technology for Devices Design and the Research Group of Cardiovascular Medicine and Metabolomics (in vitro experiments). This research received no external funding.


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