Regioselective Wacker Oxidation of Internal Alkenes: Rapid Access to Functionalized Ketones Facilitated by Cross-Metathesis

Bill Morandi, Zachary K. Wickens, Robert H. Grubbs

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Wacka wacka: The title reaction makes use of a wide range of directing groups (DG) to enable the highly regioselective oxidation of alkenes, and occurs predictably at the distal position. Both E and Z alkenes afford valuable functionalized ketones and cross-metathesis was shown to facilitate the preparation of the starting materials. BQ=benzoquinone.
Original languageEnglish (US)
Pages (from-to)9933-9936
Number of pages4
JournalAngewandte Chemie
Volume125
Issue number37
DOIs
StatePublished - Jul 26 2013
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We gratefully acknowledge financial support from the King Abdullah University of Science and Technology Centre in Development, King Fahd University of Petroleum and Minerals, the NSF, and the Swiss National Science Foundation for a fellowship to B.M.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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