Redox control of vascular biology.

Milan Obradovic, Magbubah Essack, Sonja Zafirovic, Emina Sudar-Milovanovic, Vladan P Bajic, Christophe Marc Van Neste, Andreja Trpkovic, Julijana Stanimirovic, Vladimir B. Bajic, Esma R Isenovic

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Redox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardiovascular physiology, and pathophysiology. Moreover, the topic-specific knowledgebase DES-RedoxVasc was used to develop two case studies, one focused on endothelial cells and the other on the vascular smooth muscle cells, as a starting point to possibly extend our knowledge of redox control in vascular biology.
Original languageEnglish (US)
JournalBioFactors (Oxford, England)
DOIs
StatePublished - Sep 4 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): BAS/1/1606-01-01, FCC/1/1976-17-01, FCC/1/1976-24-01
Acknowledgements: This work is part of the collaboration between the Labora-tory of Radiobiology and Molecular Genetics, Vinca Insti-tute of Nuclear Sciences, University of Belgrade, Belgrade,Serbia and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Cen-ter (CBRC), Thuwal, Saudi Arabia. This work has beensupported by grants No. 173033 (E.R.I.) from the Ministryof Education, Science and Technological Development,Republic of Serbia and by the KAUST grant OSR#4129(to E.R.I. and V.B.B.), which also supported M.O., S.Z.,E.S.M., and V.P.B. V.B.B. has been supported by the KingAbdullah University of Science and Technology BaseResearch Fund (BAS/1/1606-01-01), and V.B.B. andM.E. by KAUST Office of Sponsored Research (OSR)Awards No. FCC/1/1976-24-01 and FCC/1/1976-17-01.M.O., S.Z., E.S.M, A.T., J.S., and V.P.B. have beensupported by the grants No. 173033 (E.R.I.) and No. 173034from the Ministry of Education, Science and TechnologicalDevelopment, Republic of Serbia

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