TY - JOUR
T1 - Recent advances in polymeric electrospun nanofibers for drug delivery
AU - Sharma, Rahul
AU - Singh, Harmanpreet
AU - Joshi, Munish
AU - Sharma, Abhinandan
AU - Garg, Tarun
AU - Goyal, Amit Kumar
AU - Rath, Goutam
N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Electrospinning is a simple unit operation process by which polymeric nanofibers with diameters ranging from a few nanometers to hundreds of micrometers can be fabricated using an electrostatically operated jet of polymer solution or polymer melt. Nanofibers because of their interesting features, such as surface-to-volume ratio, high surface area, microporosity, and nonwoven structure, provide numerous opportunities to design novel carrier systems for large commodities of therapeutics. Physicochemical properties of nanofibers depend on several process and formulation parameters, such as applied voltage, flow rate, polymer selection, and concentration of polymer used. The applications of nanofibers in drug delivery are nearly unbounded. This review summarizes the most recent work done on the various physicochemical parameters of electrospinning and polymers used in making wide varieties of nanofibers along with their role in developing more effective, novel drug delivery systems. © 2014 Begell House, Inc.
AB - Electrospinning is a simple unit operation process by which polymeric nanofibers with diameters ranging from a few nanometers to hundreds of micrometers can be fabricated using an electrostatically operated jet of polymer solution or polymer melt. Nanofibers because of their interesting features, such as surface-to-volume ratio, high surface area, microporosity, and nonwoven structure, provide numerous opportunities to design novel carrier systems for large commodities of therapeutics. Physicochemical properties of nanofibers depend on several process and formulation parameters, such as applied voltage, flow rate, polymer selection, and concentration of polymer used. The applications of nanofibers in drug delivery are nearly unbounded. This review summarizes the most recent work done on the various physicochemical parameters of electrospinning and polymers used in making wide varieties of nanofibers along with their role in developing more effective, novel drug delivery systems. © 2014 Begell House, Inc.
UR - http://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,5461787910441df1,7ec883303ae32790.html
UR - http://www.scopus.com/inward/record.url?scp=84900862031&partnerID=8YFLogxK
U2 - 10.1615/CritRevTherDrugCarrierSyst.2014008193
DO - 10.1615/CritRevTherDrugCarrierSyst.2014008193
M3 - Article
SN - 0743-4863
VL - 31
SP - 187
EP - 217
JO - Critical Reviews in Therapeutic Drug Carrier Systems
JF - Critical Reviews in Therapeutic Drug Carrier Systems
IS - 3
ER -