Recent advances in electrochemical nanobiosensors for cardiac biomarkers

Masoud Negahdary, Abhinav Sharma, Thomas D. Anthopoulos, Lúcio Angnes

Research output: Contribution to journalArticlepeer-review


The WHO reports heart diseases, especially MI, are the leading cause of death. During a heart attack and damage to myocardial cells, cardiac biomarkers are released into the bloodstream. Their accurate measurement can be beneficial in the rapid screening of patients and the initiation of treatment. Rapid diagnosis of MI prevents secondary complications such as heart failure and will significantly reduce the mortality rate of patients. Electrochemical biosensors are cutting-edge diagnostic tools that successfully track the quantitative detection of several cardiac biomarkers. They are composed of three primary components: a biorecognition element, a signal transducer, and a detector. Here, the latest electrochemical biosensors developed in 2021–2023 have been collected and categorized, and their main features have been reviewed, analyzed, and compared. The most crucial biorecognition elements used in these biosensors include antibodies, oligonucleotides (especially: aptamers), and peptide sequences that are specifically selected and used to detect analytes. Equipping electrochemical biosensors with nanomaterials has increased diagnostic performance (especially sensitivity), facilitating reliable detection. These nanomaterials have been employed by modifying the surface of the signal transducer or optimizing the biorecognition element, or both. Investigating the most up-to-date platforms for detecting cardiac biomarkers and presenting their essential assembly features and diagnosis mechanisms can provide subsequent research avenues.
Original languageEnglish (US)
Pages (from-to)117104
JournalTrAC Trends in Analytical Chemistry
StatePublished - May 18 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-05-22
Acknowledged KAUST grant number(s): OSR-2019-CRG8-4095
Acknowledgements: The authors acknowledge the financial support from São Paulo Research Foundation- FAPESP (processes 2019/27021-4, 2017/13137-5 and 2014/50867-3) and from to the National Council for Research-CNPq (processes 311847-2018-8 and 465389/2014-7). Also, this work was supported by King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) under award OSR-2019-CRG8-4095. Baseline funding from KAUST is also acknowledged by T.D.A.

ASJC Scopus subject areas

  • Spectroscopy
  • Environmental Chemistry
  • Analytical Chemistry


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