Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers.

David Orive-Miguel; Laura Di Sieno; Anurag Behera; Edoardo Ferocino; Davide Contini; Laurent Condat; Lionel Hervé; Jérôme Mars; Alessandro Torricelli; Antonio Pifferi; Alberto Dalla Mora

doi:10.3390/s20102815

Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers.

David Orive-Miguel, Laura Di Sieno, Anurag Behera, Edoardo Ferocino, Davide Contini, Laurent Condat, Lionel Hervé, Jérôme Mars, Alessandro Torricelli, Antonio Pifferi, Alberto Dalla Mora

King Abdullah University of Science and Technology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength ( 670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.

Original language	English (US)
Pages (from-to)	2815
Journal	Sensors (Basel, Switzerland)
Volume	20
Issue number	10
DOIs	https://doi.org/10.3390/s20102815
State	Published - May 21 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This research has received funding from the European Union’s Horizon 2020 Marie Skodowska-Curie Innovative Training Networks (ITN-ETN) programme, under Grant Agreement No. 675332 BitMap.

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10.3390/s20102815

https://repository.kaust.edu.sa/bitstream/10754/662935/1/sensors-20-02815-v2.pdf

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Orive-Miguel, D., Di Sieno, L., Behera, A., Ferocino, E., Contini, D., Condat, L., Hervé, L., Mars, J., Torricelli, A., Pifferi, A., & Dalla Mora, A. (2020). Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers. Sensors (Basel, Switzerland), 20(10), 2815. https://doi.org/10.3390/s20102815

@article{ba558f9ff86c4b529071321d89ccc6f8,

title = "Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers.",

abstract = "Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength ( 670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.",

author = "David Orive-Miguel and {Di Sieno}, Laura and Anurag Behera and Edoardo Ferocino and Davide Contini and Laurent Condat and Lionel Herv{\'e} and J{\'e}r{\^o}me Mars and Alessandro Torricelli and Antonio Pifferi and {Dalla Mora}, Alberto",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This research has received funding from the European Union{\textquoteright}s Horizon 2020 Marie Skodowska-Curie Innovative Training Networks (ITN-ETN) programme, under Grant Agreement No. 675332 BitMap.",

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Orive-Miguel, D, Di Sieno, L, Behera, A, Ferocino, E, Contini, D, Condat, L, Hervé, L, Mars, J, Torricelli, A, Pifferi, A & Dalla Mora, A 2020, 'Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers.', Sensors (Basel, Switzerland), vol. 20, no. 10, pp. 2815. https://doi.org/10.3390/s20102815

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AU - Orive-Miguel, David

AU - Di Sieno, Laura

AU - Behera, Anurag

AU - Ferocino, Edoardo

AU - Contini, Davide

AU - Condat, Laurent

AU - Hervé, Lionel

AU - Mars, Jérôme

AU - Torricelli, Alessandro

AU - Pifferi, Antonio

AU - Dalla Mora, Alberto

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This research has received funding from the European Union’s Horizon 2020 Marie Skodowska-Curie Innovative Training Networks (ITN-ETN) programme, under Grant Agreement No. 675332 BitMap.

PY - 2020/5/21

Y1 - 2020/5/21

N2 - Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength ( 670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.

AB - Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength ( 670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.

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ER -

Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers.

Abstract

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