Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

Jing Xu; Yinbing Liu; Ke-Jing Huang; Yang-Yang Hou; Xiaoxuan Sun; Jiaqiang Li

doi:10.1021/acs.analchem.2c04278

Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

Jing Xu, Yinbing Liu, Ke-Jing Huang, Yang-Yang Hou, Xiaoxuan Sun, Jiaqiang Li

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05–10000 and 1–10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.

Original language	English (US)
Journal	Analytical Chemistry
DOIs	https://doi.org/10.1021/acs.analchem.2c04278
State	Published - Nov 29 2022

Bibliographical note

KAUST Repository Item: Exported on 2022-12-01
Acknowledgements: The authors acknowledge financial support from the Talent Introduction Start-Up Foundation of Guangxi Minzu University (2021KJQD08), Natural Science Foundation of China (No. 22074130). The authors acknowledge the support from the Analysis Testing Center of Xinyang Normal University for the materials characterization.

ASJC Scopus subject areas

Analytical Chemistry

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10.1021/acs.analchem.2c04278

Cite this

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title = "Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker",

abstract = "Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05–10000 and 1–10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.",

author = "Jing Xu and Yinbing Liu and Ke-Jing Huang and Yang-Yang Hou and Xiaoxuan Sun and Jiaqiang Li",

note = "KAUST Repository Item: Exported on 2022-12-01 Acknowledgements: The authors acknowledge financial support from the Talent Introduction Start-Up Foundation of Guangxi Minzu University (2021KJQD08), Natural Science Foundation of China (No. 22074130). The authors acknowledge the support from the Analysis Testing Center of Xinyang Normal University for the materials characterization.",

year = "2022",

month = nov,

day = "29",

doi = "10.1021/acs.analchem.2c04278",

language = "English (US)",

journal = "Analytical Chemistry",

issn = "0003-2700",

publisher = "American Chemical Society",

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T1 - Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

AU - Xu, Jing

AU - Liu, Yinbing

AU - Huang, Ke-Jing

AU - Hou, Yang-Yang

AU - Sun, Xiaoxuan

AU - Li, Jiaqiang

N1 - KAUST Repository Item: Exported on 2022-12-01 Acknowledgements: The authors acknowledge financial support from the Talent Introduction Start-Up Foundation of Guangxi Minzu University (2021KJQD08), Natural Science Foundation of China (No. 22074130). The authors acknowledge the support from the Analysis Testing Center of Xinyang Normal University for the materials characterization.

PY - 2022/11/29

Y1 - 2022/11/29

N2 - Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05–10000 and 1–10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.

AB - Realization of a highly sensitive analysis and sensing platform is important for early-stage tumor diagnosis. In this work, a self-powered biosensor with a novel sandwich graphdiyne (SGDY) combined with an aptamer-specific recognition function was developed to sensitively and accurately detect tumor markers. Results indicated that the detection limits of microRNA (miRNA)-21 and miRNA-141 were 0.15 and 0.30 fM (S/N = 3) in the linear range of 0.05–10000 and 1–10000 fM, respectively. The newly designed platform has great promise for early-stage tumor diagnosis.

UR - http://hdl.handle.net/10754/686047

UR - https://pubs.acs.org/doi/10.1021/acs.analchem.2c04278

U2 - 10.1021/acs.analchem.2c04278

DO - 10.1021/acs.analchem.2c04278

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SN - 0003-2700

JO - Analytical Chemistry

JF - Analytical Chemistry

ER -

Real-Time Biosensor Platform Based on Novel Sandwich Graphdiyne for Ultrasensitive Detection of Tumor Marker

Abstract

Bibliographical note

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